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Coexisting fast-slow dendritic traveling waves in a 3D-array electric field coupled neuronal network |
| Xile Wei(魏熙乐)1, Zeyu Ren(任泽宇)1, Meili Lu(卢梅丽)2, Yaqin Fan(樊亚琴)1, and Siyuan Chang(常思远)1,† |
1 The Tianjin Key Laboratory of Process Measurement and Control, School of Electrical and Information Engineering, Tianjin University, Tianjin 300072, China;
2 School of Information Technology Engineering, Tianjin University of Technology and Education, Tianjin 300074, China |
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Abstract Coexistence of fast and slow traveling waves without synaptic transmission has been found in hhhippocampal tissues, which is closely related to both normal brain activity and abnormal neural activity such as epileptic discharge. However, the propagation mechanism behind this coexistence phenomenon remains unclear. In this paper, a three-dimensional electric field coupled hippocampal neural network is established to investigate generation of coexisting spontaneous fast and slow traveling waves. This model captures two types of dendritic traveling waves propagating in both transverse and longitude directions: the N-methyl-D-aspartate (NMDA)-dependent wave with a speed of about 0.1m/s and the Ca-dependent wave with a speed of about 0.009m/s. These traveling waves are synaptic-independent and could be conducted only by the electric fields generated by neighboring neurons, which are basically consistent with the in vitro data measured experiments. It is also found that the slow Ca wave could trigger generation of fast NMDA waves in the propagation path of slow waves whereas fast NMDA waves cannot affect the propagation of slow Ca waves. These results suggest that dendritic Ca waves could acted as the source of the coexistence fast and slow waves. Furthermore, we also confirm the impact of cellular spacing heterogeneity on the onset of coexisting fast and slow waves. The local region with decreasing distances among neighbor neurons is more liable to promote the onset of spontaneous slow waves which, as sources, excite propagation of fast waves. These modeling studies provide possible biophysical mechanisms underlying the neural dynamics of spontaneous traveling waves in brain tissues.
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Received: 15 December 2023
Revised: 05 March 2024
Accepted manuscript online: 11 March 2024
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PACS:
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87.19.lq
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(Neuronal wave propagation)
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87.19.ll
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(Models of single neurons and networks)
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87.19.lj
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(Neuronal network dynamics)
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07.05.Tp
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(Computer modeling and simulation)
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| Fund: This work was supported in part by the National Natural Science Foundation of China (Grant Nos. 62171312 and 61771330) and the Tianjin Municipal Education Commission Scientific Research Project (Grant No. 2020KJ114). |
Corresponding Authors:
Siyuan Chang
E-mail: changsiyuan@tju.edu.cn
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Cite this article:
Xile Wei(魏熙乐), Zeyu Ren(任泽宇), Meili Lu(卢梅丽), Yaqin Fan(樊亚琴), and Siyuan Chang(常思远) Coexisting fast-slow dendritic traveling waves in a 3D-array electric field coupled neuronal network 2024 Chin. Phys. B 33 068702
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