Uncovering the underlying physical mechanisms of biological systems via quantification of landscape and flux

doi:10.1088/1674-1056/25/1/016401

Abstract

In this review, we explore the physical mechanisms of biological processes such as protein folding and recognition, ligand binding, and systems biology, including cell cycle, stem cell, cancer, evolution, ecology, and neural networks. Our approach is based on the landscape and flux theory for nonequilibrium dynamical systems. This theory provides a unifying principle and foundation for investigating the underlying mechanisms and physical quantification of biological systems.

Keywords: landscape flux

Received: 08 May 2015
Revised: 08 October 2015
Accepted manuscript online:

PACS:	64.60.aq	(Networks)
	87.18.Vf	(Systems biology)
	87.19.ll	(Models of single neurons and networks)
	87.23.-n	(Ecology and evolution)

Fund:

Project supported by the Natural Science Foundation of China (Grant Nos. 21190040, 11174105, 91225114, 91430217, and 11305176) and Jilin Province Youth Foundation, China (Grant No. 20150520082JH).

Corresponding Authors: Li Xu, Jin Wang
E-mail: jin.wang.1@stonybrook.edu

Cite this article:

Li Xu(徐丽), Xiakun Chu(楚夏昆), Zhiqiang Yan(晏致强), Xiliang Zheng(郑喜亮), Kun Zhang(张坤), Feng Zhang(张锋), Han Yan(闫晗), Wei Wu(吴畏), Jin Wang(汪劲) Uncovering the underlying physical mechanisms of biological systems via quantification of landscape and flux 2016 Chin. Phys. B 25 016401

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