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Effects of abnormal excitation on the dynamics of spiral waves |
Min-Yi Deng(邓敏艺), Xue-Liang Zhang(张学良), Jing-Yu Dai(戴静娱) |
College of Physical Science and Technology, Guangxi Normal University, Guilin 541004, China |
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Abstract The effect of physiological and pathological abnormal excitation of a myocyte on the spiral waves is investigated based on the cellular automaton model. When the excitability of the medium is high enough, the physiological abnormal excitation causes the spiral wave to meander irregularly and slowly. When the excitability of the medium is low enough, the physiological abnormal excitation leads to a new stable spiral wave. On the other hand, the pathological abnormal excitation destroys the spiral wave and results in the spatiotemporal chaos, which agrees with the clinical conclusion that the early after depolarization is the pro-arrhythmic mechanism of some anti-arrhythmic drugs. The mechanisms underlying these phenomena are analyzed.
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Received: 29 June 2015
Revised: 14 August 2015
Accepted manuscript online:
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PACS:
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05.45.-a
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(Nonlinear dynamics and chaos)
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87.18.Hf
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(Spatiotemporal pattern formation in cellular populations)
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Fund: Project supported by the National Natural Science Foundation of China (Grant Nos. 11365003 and 11165004). |
Corresponding Authors:
Min-Yi Deng
E-mail: dengminyi@mailbox.gxnu.edu.cn
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Cite this article:
Min-Yi Deng(邓敏艺), Xue-Liang Zhang(张学良), Jing-Yu Dai(戴静娱) Effects of abnormal excitation on the dynamics of spiral waves 2016 Chin. Phys. B 25 010504
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