Numerical study of the coupling between F0 with varied numbers of c-subunits and F1 in an ATP synthase
Qian Jun (钱钧), Xie Ping (谢平), Dou Shuo-Xing (窦硕星), Wang Peng-Ye (王鹏业)
Laboratory of Soft Matter Physics, Beijing National Laboratory for Condensed Matter Physics,Institute of Physics, Chinese Academy of Sciences, Beijing 100080, China
Abstract ATP synthase is a rotary motor which is composed of two portions: the `rotor' F0, consisting of a c-ring, and the `stator' F1, consisting of an $\alpha$3$\beta$3 hexamer. In different species, the number of c-subunits which form the c-ring is varied from 10 to 14, whereas the $\alpha$3$\beta$3 hexamer is fixed to be 3-fold symmetrical. We have numerically studied the rotational coupling between F0 with varied number of c-subunits and F1. It is found that, for any number of c-subunits, the rotor F0 advances 3 steps per revolution on average, which is determined by the period of F1, whereas the exact angular pausing positions are determined by the period of F0. When the symmetry of the c-ring of F0 is matched with the 3-fold symmetry of F1, the three steps have equivalent sizes. If not matched, the three steps become nonequivalent: both the step size and average dwell time are different for these steps.
Received: 18 March 2005
Revised: 19 August 2005
Accepted manuscript online:
Fund: Project supported by the National Natural Science Foundation of China (Grant Nos 60025516 and 10334100).
Cite this article:
Qian Jun (钱钧), Xie Ping (谢平), Dou Shuo-Xing (窦硕星), Wang Peng-Ye (王鹏业) Numerical study of the coupling between F0 with varied numbers of c-subunits and F1 in an ATP synthase 2005 Chinese Physics 14 2214
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