INTERDISCIPLINARY PHYSICS AND RELATED AREAS OF SCIENCE AND TECHNOLOGY |
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Electron beam irradiation on novel coronavirus (COVID-19): A Monte-Carlo simulation |
Guobao Feng(封国宝)1, Lu Liu(刘璐)2, Wanzhao Cui(崔万照)1, Fang Wang(王芳)3 |
1 National Key Laboratory of Science and Technology on Space Microwave, China Academy of Space Technology, Xi'an 710000, China; 2 School of Computer Science and Engineering, Xi'an University of Technology, Xi'an 710048, China; 3 Key Laboratory for Physical Electronics and Devices of the Ministry of Education, Xi'an Jiaotong University, Xi'an 710049, China |
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Abstract The novel coronavirus pneumonia triggered by COVID-19 is now raging the whole world. As a rapid and reliable killing COVID-19 method in industry, electron beam irradiation can interact with virus molecules and destroy their activity. With the unexpected appearance and quickly spreading of the virus, it is urgently necessary to figure out the mechanism of electron beam irradiation on COVID-19. In this study, we establish a virus structure and molecule model based on the detected gene sequence of Wuhan patient, and calculate irradiated electron interaction with virus atoms via a Monte Carlo simulation that track each elastic and inelastic collision of all electrons. The characteristics of irradiation damage on COVID-19, atoms' ionizations and electron energy losses are calculated and analyzed with regions. We simulate the different situations of incident electron energy for evaluating the influence of incident energy on virus damage. It is found that under the major protecting of an envelope protein layer, the inner RNA suffers the minimal damage. The damage for a ~100-nm-diameter virus molecule is not always enhanced by irradiation energy monotonicity, for COVID-19, the irradiation electron energy of the strongest energy loss damage is 2 keV.
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Received: 17 February 2020
Revised: 20 February 2020
Accepted manuscript online:
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PACS:
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87.15.-v
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(Biomolecules: structure and physical properties)
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61.80.Fe
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(Electron and positron radiation effects)
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52.65.Pp
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(Monte Carlo methods)
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Fund: Project supported by the National Natural Science Foundation of China (Grant No. 61901360). |
Corresponding Authors:
Wanzhao Cui
E-mail: cuiwanzhao@126.com
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Cite this article:
Guobao Feng(封国宝), Lu Liu(刘璐), Wanzhao Cui(崔万照), Fang Wang(王芳) Electron beam irradiation on novel coronavirus (COVID-19): A Monte-Carlo simulation 2020 Chin. Phys. B 29 048703
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[1] |
Guan W J, Ni Z Y, Hu Yu et al. 2020 New Engl. J. Med. (in press)
|
[2] |
http://www.nhc.gov.cn/wjw/zxfb/list.shtml
|
[3] |
Van E, Terpstra F G and Schuitemaker H 2002 J. Hosp. Infect. 51 121
|
[4] |
Nevelsky A, Borzov E and Daniel S 2017 J. Appl. Clin. Med. Phys. 18 196
|
[5] |
Jasmin F, Lea B, Thomas G et al. 2013 Viruses 8 319
|
[6] |
Smolko E E and Lombardo J H 2005 Nucl. Instrum. Meth. B 236 249
|
[7] |
Luchsinger S E, Kropf D H, García-Zepeda C M et al. 2006 J. Food Sci. 61 1000
|
[8] |
Lea B, Jasmin F and Sebastian U 2018 Vaccine 36 1561
|
[9] |
Sabbaghi A, Miri S M, Keshavarz M et al. 2019 Rev. Med. Virol. 29 2074
|
[10] |
https://www.niaid.nih.gov/news-events/novel-coronavirus-sarscov2-images
|
[11] |
Brahmakshatriya V, Lupiani B and Brinlee J L 2009 Avian. Pathol. 38 245
|
[12] |
Chandni P, Brooke A D and David H K 2013 Appl. Environ. Microb. 79 3796
|
[13] |
Tanja S, Arnd T H and Uwe G 2012 Transfus. Med. Hemoth. 39 29
|
[14] |
Zhang T, Li Z and Tao J 2013 Chin. Animal Health Inspection 30 52 (in Chinese)
|
[15] |
Xu X T, Chen P and Wang J F, Feng J N, Zhou H, Li X, Zhong W and Hao P 2020 Sci. Chin. Life Sci. 63 457
|
[16] |
Xu Z J, Peng C and Shi Y L 2020 Sci. Chin. Life Sci. (in press)
|
[17] |
Lu R J, Zhao X and Li J 2020 Lancet 395 565
|
[18] |
Malik Y S, Sircar S and Bhat S 2020 Vet. Quart. 40 68
|
[19] |
https://www.pptaglobal.org/media-and-information/ppta-statements/ 1055-2019-novel-coronavirus-2019-ncov-and-plasma-protein-therapies
|
[20] |
https://www.ncbi.nlm.nih.gov/nuccore/NC_045512.2/
|
[21] |
https://www.ncbi.nlm.nih.gov/nuccore/MN908947
|
[22] |
Feng G B, Cui W Z and Zhang N 2017 Chin. Phys. B 26 097901
|
[23] |
Feng G B, Liu L and Cui W Z 2019 IEEE Trans. Plas. Sci. 47 3783
|
[24] |
Feng G B, Wang F and Hu T C 2015 Chin. Phys. B 24 117901
|
[25] |
Chang C, Tang C X and Wu J H 2013 Phys. Rev. Lett. 110 064802
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