Radiation-induced robust oscillation and non-Gaussian fluctuation

doi:10.1088/1674-1056/20/12/128702

Abstract There have been many recent studies devoted to the consequences of stochasticity in protein circuitry. Stress conditions, including DNA damage, hypoxia, heat shock, nutrient deprivation, and oncogene activation, can result in the activation and accumulation of p53. Several experimental studies show that oscillations can be induced by DNA damage following nuclear irradiation. To explore the underlying dynamical features and the role of stochasticity, we discuss the oscillatory dynamics in the well-studied regulatory network motif. The fluctuations around the fixed point of a delayed system are Gaussian in the limit of sufficiently weak delayed feedback, and remain Gaussian along a limit cycle when viewed tangential to the trajectory. The experimental results are recapitulated in this study. We illustrate several features of the p53 activities, which are robust when the parameters change. Furthermore, the distribution in protein abundance can be characterized by its non-Gaussian nature.

Keywords: nuclear radiation DNA damage non-Gaussian activity robustness

Received: 07 September 2010
Revised: 16 August 2011
Accepted manuscript online:

PACS:	87.16.Yc	(Regulatory genetic and chemical networks)
	87.18.Tt	(Noise in biological systems)
	05.40.-a	(Fluctuation phenomena, random processes, noise, and Brownian motion)

Fund: Project supported by the National Natural Science Foundation of China (Grant No. 10975019), the Scientific Research Foundation for the Returned Overseas Chinese Scholars, Ministry of Personnel of China (Grant No. MOP2006138), the Fundamental Research Funds for the Central Universities, and the Science Foundation of the Ministry of Science and Technology of China (Grant No. 2012CB934001).

Cite this article:

Liu Bo(刘波), Yan Shi-Wei (晏世伟), and Geng Yi-Zhao(耿轶钊) Radiation-induced robust oscillation and non-Gaussian fluctuation 2011 Chin. Phys. B 20 128702

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