Abstract In circadian rhythm generation, intercellular signaling factors are shown to play a crucial role in both sustaining intrinsic cellular rhythmicity and acquiring collective behaviours across a population of circadian neurons. However, the physical mechanism behind their role remains to be fully understood. In this paper, we propose an indirectly coupled multicellular model for the synchronization of Drosophila circadian oscillators combining both intracellular and intercellular dynamics. By simulating different experimental conditions, we find that such an indirect coupling way can synchronize both heterogeneous self-sustained circadian neurons and heterogeneous mutational damped circadian neurons. Moreover, they can also be entrained to ambient light--dark (LD) cycles depending on intercellular signaling.
Received: 19 August 2008
Revised: 08 September 2008
Accepted manuscript online:
Fund: Project supported by the State Key
Program of National Natural Science Foundation of China (Grant No
60736028), the National Natural Science Foundation of China (Grant
Nos 60704045 and 10871074), and Research Fund for the Doctoral
Program of Higher Educat
Cite this article:
Wang Jun-Wei(王军威), Chen Ai-Min(陈爱敏), Zhang Jia-Jun(张家军), Yuan Zhan-Jiang(苑占江), and Zhou Tian-Shou(周天寿) Modeling of intercellular synchronization in the Drosophila circadian clock 2009 Chin. Phys. B 18 1294
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