Circular dichroism spectra of α -lactose molecular measured by terahertz time-domain spectroscopy
Chun Wang(王春)1,2, Bo Wang(王博)1,2, Gaoshuai Wei(魏高帅)1,2, Jianing Chen(陈佳宁)1, and Li Wang(汪力)1,†
1. Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100190, China; 2. School of Physical Sciences, University of Chinese Academy of Sciences, Beijing 100049, China
Abstract Researchers have long studied circular dichroism (CD) for its enormous prospects in life sciences. Many biomolecules have vibration modes in the terahertz region, and terahertz CD spectra are robust to detect biomolecular structures. However, few studies explore the terahertz CD spectra on even natural materials due to technical challenges in both fields. Here, we report a setup of home-built terahertz time-domain spectroscopy to measure the polarization states of terahertz waves. By carefully measuring the transmission Jones matrix, we obtain terahertz CD spectra of α -lactose tablets and D-glucose tablets. Our results show that the terahertz CD spectra are sensitive to vibrational motions in biochemical compounds, which will find wide applications in biosensing and biomedical diagnostics.
Fund: Project supported by the National Natural Science Foundation of China (Grant No. 61775233).
Corresponding Authors:
Li Wang
E-mail: wangli@aphy.iphy.ac.cn
Cite this article:
Chun Wang(王春), Bo Wang(王博), Gaoshuai Wei(魏高帅), Jianing Chen(陈佳宁), and Li Wang(汪力) Circular dichroism spectra of α -lactose molecular measured by terahertz time-domain spectroscopy 2022 Chin. Phys. B 31 104201
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