Astrocyte and ions metabolism during epileptogenesis: A review for modeling studies

doi:10.1088/1674-1056/ab6961

Abstract As a large group of cells in a central nervous system, astrocytes have a great influence on ion and energy metabolism in a nervous system. Disorders of neuronal ion and energy metabolism caused by impaired astrocytes play a key role in the pathogenesis of epilepsy. This paper reviews the existing computational models of epileptogenesis resulting from impaired astrocytes and presents several open perspectives with regard to ion and energy metabolism-induced epileptogenesis in a neuron-astrocyte-capillary coupled model.

Keywords: epileptogenesis astrocyte potassium glutamate

Received: 22 October 2019
Revised: 23 December 2019
Accepted manuscript online:

PACS:	87.19.lk	(Glia)
	87.19.ll	(Models of single neurons and networks)
	87.19.L-	(Neuroscience)
	87.19.lj	(Neuronal network dynamics)

Fund: Project supported by the National Natural Science Foundation of China (Grant No. 11772242).

Corresponding Authors: Ying Wu
E-mail: wying36@xjtu.edu.cn

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Meng-Meng Du(独盟盟), Jia-Jia Li(李佳佳), Zhi-Xuan Yuan(袁治轩), Yong-Chen Fan(范永晨), Ying Wu(吴莹) Astrocyte and ions metabolism during epileptogenesis: A review for modeling studies 2020 Chin. Phys. B 29 038701

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Astrocyte and ions metabolism during epileptogenesis: A review for modeling studies

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