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Chin. Phys. B, 2023, Vol. 32(2): 020502    DOI: 10.1088/1674-1056/ac6dbc
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Epilepsy dynamics of an astrocyte-neuron model with ammonia intoxication

Zhixuan Yuan(袁治轩)1, Mengmeng Du(独盟盟)2, Yangyang Yu(于羊羊)1, and Ying Wu(吴莹)1,†
1 State Key Laboratory for Strength and Vibration of Mechanical Structures, Shaanxi Engineering Laboratory for Vibration Control of Aerospace Structures, School of Aerospace Engineering, Xi'an Jiaotong University, Xi'an 710049, China;
2 School of Mathematics and Data Science, Shaanxi University of Science and Technology, Xi'an 710000, China
Abstract  Experimental records in the cerebral cortex indicate that ammonia injection can lead to seizures. Considering that astrocytes play a vital role in mediating the uptake and absorption of ammonium ions in the extracellular space of the cortical circuit, we constructed a new astrocyte neuron coupling model, which is composed of a neuron and its astrocytes connected through the extracellular space, taking into account of the influence of extracellular ammonium ions. The numerical results verified the previous experimental observation that obtained epileptic firing modes of neurons and postsynaptic GABA reversal potential depolarization triggered by ammonia injection. In addition, we also determined the concentration-response relationship between the ammonium ion concentration and the time of entering epilepsy and predicted the threshold of the ammonium ion concentration for the onset of epilepsy.
Keywords:  ammonia      neuron      astrocyte      epilepsy  
Received:  05 February 2022      Revised:  10 April 2022      Accepted manuscript online:  07 May 2022
PACS:  05.45.-a (Nonlinear dynamics and chaos)  
  64.70.qj (Dynamics and criticality)  
  87.19.L- (Neuroscience) (Glia)  
Fund: Project supported by the National Natural Science Foundation of China (Grant Nos. 12132012 and 11972275) and the National Science Foundation for Young Scientists of China (Grant No. 12102240).
Corresponding Authors:  Ying Wu     E-mail:

Cite this article: 

Zhixuan Yuan(袁治轩), Mengmeng Du(独盟盟), Yangyang Yu(于羊羊), and Ying Wu(吴莹) Epilepsy dynamics of an astrocyte-neuron model with ammonia intoxication 2023 Chin. Phys. B 32 020502

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