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Influence of matrigel on the shape and dynamics of cancer cells |
| Teng Ye(叶腾)1, Feng Qiu(邱峰)1,2 |
| First Clinical Medical College, Nanchang University, Nanchang, China, Department of Oncology, First Affiliated Hospital of Nanchang University, Nanchang, China |
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Abstract The interaction between extracellular matrices and cancer cells plays an important role in regulating cancer cell behaviors. In this article, we use matrigel to mimic extracellular matrices and investigate experimentally how matrigel influences the shape and dynamics of breast cancer cells (MDA-MB-231-GFP cells). We find that matrigel facilitates cancer cells' migration and shape deformation. The influences of the matrigel concentration are also reported.
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Received: 28 August 2019
Revised: 06 September 2019
Accepted manuscript online:
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PACS:
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87.17.-d
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(Cell processes)
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87.17.Jj
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(Cell locomotion, chemotaxis)
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87.18.Ed
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(Cell aggregation)
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05.40.Jc
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(Brownian motion)
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Corresponding Authors:
Feng Qiu
E-mail: lukeqiubmu@163.com
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Cite this article:
Teng Ye(叶腾), Feng Qiu(邱峰) Influence of matrigel on the shape and dynamics of cancer cells 2019 Chin. Phys. B 28 108704
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