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Chin. Phys. B, 2021, Vol. 30(9): 090502    DOI: 10.1088/1674-1056/abf557
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Migration and shape of cells on different interfaces

Xiaochen Wang(王晓晨)1,2, Qihui Fan (樊琪慧)1, and Fangfu Ye(叶方富)1,2,3,4,†
1 Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100190, China;
2 School of Physical Sciences, University of Chinese Academy of Sciences, Beijing 100049, China;
3 Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325000, China;
4 Songshan Lake Materials Laboratory, Dongguan 523808, China
Abstract  Impacts of microenvironments on cell migration have been reported in various interaction modes. A rapid tumor metastasis occurs along topological interfaces in vivo, such as the interface between the blood vessels and nerves. In this work, we culture MDA-MB231 cells at dish-liquid, dish-hydrogel, and hydrogel-liquid interfaces, respectively, to study how these different interfaces influence cell dynamics and morphology. Our results show that the migration mode of cells changes from an amoeboid motion to a mesenchymal motion but their speed do not change obviously if the interface changes from hydrogel-liquid to dish-liquid. In contrast, the migration mode of cells at a dish-hydrogel interface maintains as a mesenchymal motion, whereas their speed increases significantly.
Keywords:  extracellular matrix      cell migration      cell morphology      migration mode  
Received:  29 March 2021      Accepted manuscript online:  07 April 2021
PACS:  05.40.Jc (Brownian motion)  
  87.10.-e (General theory and mathematical aspects)  
  87.17.-d (Cell processes)  
Fund: Project supported by the National Natural Science Foundation of China (Grant Nos. 11774394 and 11704404), the Chinese Academy of Sciences (CAS), and the Key Research Program of Frontier Sciences of CAS (Grant No. QYZDB-SSW-SYS003).
Corresponding Authors:  Fangfu Ye     E-mail:

Cite this article: 

Xiaochen Wang(王晓晨), Qihui Fan (樊琪慧), and Fangfu Ye(叶方富) Migration and shape of cells on different interfaces 2021 Chin. Phys. B 30 090502

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