|
|
|
Migration and shape of cells on different interfaces |
| Xiaochen Wang(王晓晨)1,2, Qihui Fan (樊琪慧)1, and Fangfu Ye(叶方富)1,2,3,4,† |
1 Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100190, China;
2 School of Physical Sciences, University of Chinese Academy of Sciences, Beijing 100049, China;
3 Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325000, China;
4 Songshan Lake Materials Laboratory, Dongguan 523808, China |
|
|
|
|
Abstract Impacts of microenvironments on cell migration have been reported in various interaction modes. A rapid tumor metastasis occurs along topological interfaces in vivo, such as the interface between the blood vessels and nerves. In this work, we culture MDA-MB231 cells at dish-liquid, dish-hydrogel, and hydrogel-liquid interfaces, respectively, to study how these different interfaces influence cell dynamics and morphology. Our results show that the migration mode of cells changes from an amoeboid motion to a mesenchymal motion but their speed do not change obviously if the interface changes from hydrogel-liquid to dish-liquid. In contrast, the migration mode of cells at a dish-hydrogel interface maintains as a mesenchymal motion, whereas their speed increases significantly.
|
Received: 29 March 2021
Accepted manuscript online: 07 April 2021
|
|
PACS:
|
05.40.Jc
|
(Brownian motion)
|
| |
87.10.-e
|
(General theory and mathematical aspects)
|
| |
87.17.-d
|
(Cell processes)
|
|
| Fund: Project supported by the National Natural Science Foundation of China (Grant Nos. 11774394 and 11704404), the Chinese Academy of Sciences (CAS), and the Key Research Program of Frontier Sciences of CAS (Grant No. QYZDB-SSW-SYS003). |
Corresponding Authors:
Fangfu Ye
E-mail: fye@iphy.ac.cn
|
Cite this article:
Xiaochen Wang(王晓晨), Qihui Fan (樊琪慧), and Fangfu Ye(叶方富) Migration and shape of cells on different interfaces 2021 Chin. Phys. B 30 090502
|
[1] Rowe R G and Weiss S J 2009 Annu. Rev. Cell Dev. Biol. 25 567
[2] Christine L and Chaffer R A W 2011 Science 331 1559
[3] Wirtz D, Konstantopoulos K and Searson P C 2011 Nat. Rev. Cancer 11 512
[4] Paul C D, Mistriotis P and Konstantopoulos K 2017 Nat. Rev. Cancer 17 131
[5] Bentolila L A, Prakash R, Mihic-Probst D, Wadehra M, Kleinman H K, Carmichael T S, Péault B, Barnhill R L and Lugassy C 2016 Sci. Rep. 6 23834
[6] Quail D F and Joyce J A 2017 Cancer. Cell 31 326
[7] Wells R G 2008 Hepatology 47 1394
[8] Muhammad H, Zaman L M T, Alisha L, Sieminski, Drew MacKellar, Haiyan Gong, Roger D. Kamm, Alan Wells, Douglas A. Lauffenburger and Paul Matsudaira 2006 Proc. Natl. Acad. Sci. USA 103 10889
[9] Pathak A and Kumar S 2011 Integr. Biol. 3 267
[10] Petrie R J, Gavara N, Chadwick R S and Yamada K M 2012 J. Cell Biol. 197 439
[11] Petrie R J and Yamada K M 2012 J. Cell Sci. 125 5917
[12] Rape A D and Kumar S 2014 Biomaterials 35 8846
[13] Wu P H, Giri A, Sun S X and Wirtz D 2014 Proc. Natl. Acad. Sci. USA 111 3949
[14] Friedl P and Wolf K 2010 J. Cell Biol. 188 11
[15] Lammermann T and Sixt M 2009 Curr. Opin. Cell Biol. 21 636
[16] Ruprecht V, Wieser S, Callan-Jones A, Smutny M, Morita H, Sako K, Barone V, Ritsch-Marte M, Sixt M, Voituriez R and Heisenberg C P 2015 Cell 160 673
[17] Liu Y P, Zhang X C, Wu Y L, Liu W, Li X, Liu R C, Liu L Y and Shuai J W 2017 Chin. Phys. B 26 128707
[18] Dix J A and Verkman A S 2008 Annu. Rev. Biophys. 37 247
[19] Mierke C T 2015 Cell Adh. Migr. 9 367
[20] Mah E J, Lefebvre A, McGahey G E, Yee A F and Digman M A 2018 Sci. Rep. 8 17094
[21] Doyle A D, Kutys M L, Conti M A, Matsumoto K, Adelstein R S and Yamada K M 2012 J. Cell Sci. 125 2244
[22] Schwarz U S and Gardel M L 2012 J. Cell Sci. 125 3051 |
| No Suggested Reading articles found! |
|
|
Viewed |
|
|
|
Full text
|
|
|
|
|
Abstract
|
|
|
|
|
Cited |
|
|
|
|
Altmetric
|
|
blogs
Facebook pages
Wikipedia page
Google+ users
|
Online attention
Altmetric calculates a score based on the online attention an article receives. Each coloured thread in the circle represents a different type of online attention. The number in the centre is the Altmetric score. Social media and mainstream news media are the main sources that calculate the score. Reference managers such as Mendeley are also tracked but do not contribute to the score. Older articles often score higher because they have had more time to get noticed. To account for this, Altmetric has included the context data for other articles of a similar age.
View more on Altmetrics
|
|
|
