On load dependence of detachment rate of kinesin motor

doi:10.1088/1674-1056/ad8ec7

Abstract Kinesin is an archetypal microtubule-based molecular motor that can generate force to transport cargo in cells. The load dependence of the detachment rate is an important factor of the kinesin motor, the determination of which is critically related to the chemomechanical coupling mechanism of the motor. Here, we use three models for the load dependence of the detachment rate of the kinesin motor to study theoretically and numerically the maximal force generated and microtubule-attachment duration of the motor. By comparing the theoretical and numerical results with the available experimental data, we show that only one model can explain well the available experimental data, indicating that only this model can be applicable to the kinesin motor.

Keywords: kinesin detachment rate generated force chemomechanical coupling mechanism optical trapping

Received: 13 September 2024
Revised: 12 October 2024
Accepted manuscript online: 05 November 2024

PACS:	87.10.Tf	(Molecular dynamics simulation)
	87.15.A-	(Theory, modeling, and computer simulation)
	87.15.hg	(Dynamics of intermolecular interactions)

Fund: Project supported by Youth Project of Science and Technology Research Program of Chongqing Education Commission of China (Grant No. KJQN202404522).

Corresponding Authors: Ping Xie
E-mail: pxie@iphy.ac.cn

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Xiao-Xuan Shi(史晓璇), Yao Wang(王瑶), Yu-Ru Liu(刘玉如), and Ping Xie(谢平) On load dependence of detachment rate of kinesin motor 2025 Chin. Phys. B 34 018702

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On load dependence of detachment rate of kinesin motor

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