Hexagonal arrangement of phospholipids in bilayer membranes

doi:10.1088/1674-1056/ab7187

Abstract The phospholipid membrane plays a key role in myriad biological processes and phenomena, and the arrangement structure of membrane determines its function. However, the molecular arrangement structure of phospholipids in cell membranes is difficult to detect experimentally. On the basis of molecular dynamic simulations both in a non-destructive way and at native environment, we observed and confirmed that the phospholipids self-assemble to a hexagonal arrangement structure under physiological conditions. The underlying mechanism was revealed to be that there are hexagonal arrangement regions with a lower free energy around each lipid molecule. The findings potentially advance the understanding of biological functions of phospholipid bilayers.

Keywords: phospholipid bilayer bio-membrane structure molecular dynamic simulation self-assemble

Received: 11 December 2019
Revised: 20 January 2020
Accepted manuscript online:

PACS:	05.20.-y	(Classical statistical mechanics)
	05.70.Np	(Interface and surface thermodynamics)
	83.10.Rs	(Computer simulation of molecular and particle dynamics)
	87.14.Cc	(Lipids)

Fund: Project supported by the National Natural Science Foundation of China (Grant No. 11904231), the National Key R&D Program of China (Grant Nos. 2018YFE0205501 and 2018YFB1801500), and Shanghai Sailing Program, China (Grant No. 19YF1434100).

Corresponding Authors: Zhi Zhu
E-mail: zhuzhi@usst.edu.cn

Cite this article:

Xiao-Wei Chen(陈晓伟), Ming-Xia Yuan(元明霞), Han Guo(郭晗), Zhi Zhu(朱智) Hexagonal arrangement of phospholipids in bilayer membranes 2020 Chin. Phys. B 29 030505

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