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Chin. Phys. B, 2017, Vol. 26(3): 030503    DOI: 10.1088/1674-1056/26/3/030503
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Effects of time delays in a mathematical bone model

Li-Fang Wang(王莉芳)1, Kang Qiu(仇康)1,2, Ya Jia(贾亚)1
1 Institute of Biophysics and Department of Physics, Central China Normal University, Wuhan 430079, China;
2 Department of Mathematics and Physics, Xuzhou Medical University, Xuzhou 221004, China
Abstract  In this paper we propose a mathematical model of bone remodeling with time delays of both osteoclast-derived paracrine signaling of tumor and tumor-derived paracrine signaling of osteoclast. The effects of time delays on the growth of tumor cells and bone system are studied in multiple myeloma-induced bone disease. In the case of small osteoclast-derived paracrine signaling, it is found that the growth of tumor cells slows down, the oscillation period of the ratio of osteoclasts to osteoblasts is extended with increasing time delay, and there is a competition between the delay and osteoclast-derived paracrine signaling. In the case of large tumor-derived paracrine signaling, the tumor-derived paracrine signaling can induce a more significant decline in tumor growth for long time delay, and thus slowing down the progression of bone disease. There is an optimal coupling between the tumor-derived paracrine signaling of osteoclasts and time delay during the progressions of bone diseases, which suppresses the tumor growth and the regression of bone disease.
Keywords:  time delays      oscillation      model of bone remodeling  
Received:  09 November 2016      Revised:  12 December 2016      Accepted manuscript online: 
PACS:  05.45.-a (Nonlinear dynamics and chaos)  
  87.17.Aa (Modeling, computer simulation of cell processes)  
  87.18.Vf (Systems biology)  
Fund: Project supported by the National Natural Science Foundation of China (Grant No. 11474117).
Corresponding Authors:  Ya Jia     E-mail:

Cite this article: 

Li-Fang Wang(王莉芳), Kang Qiu(仇康), Ya Jia(贾亚) Effects of time delays in a mathematical bone model 2017 Chin. Phys. B 26 030503

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