Analysis of detection limit to time-resolved coherent anti-Stokes Raman scattering nanoscopy

doi:10.1088/1674-1056/23/10/104202

Abstract In the implementation of CARS nanoscopy, signal strength decreases with focal volume size decreasing. A crucial problem that remains to be solved is whether the reduced signal generated in the suppressed focal volume can be detected. Here reported is a theoretical analysis of detection limit (DL) to time-resolved CARS (T-CARS) nanoscopy based on our proposed additional probe-beam-induced phonon depletion (APIPD) method for the low concentration samples. In order to acquire a detailed shot-noise limited signal-to-noise (SNR) and the involved parameters to evaluate DL, the T-CARS process is described with full quantum theory to estimate the extreme power density levels of the pump and Stokes beams determined by saturation behavior of coherent phonons, which are both actually on the order of ～ 10¹⁹ W/cm². When the pump and Stokes intensities reach such values and the total intensity of the excitation beams arrives at a maximum tolerable by most biological samples in a certain suppressed focal volume (40-nm suppressed focal scale in APIPD method), the DL correspondingly varies with exposure time, for example, DL values are 10³ and 10² when exposure times are 20 ms and 200 ms respectively.

Keywords: break through the diffraction limit coherent anti-Stokes Raman scattering nonlinear optics detection limit

Received: 26 December 2013
Revised: 14 March 2014
Accepted manuscript online:

PACS:	42.25.Fx	(Diffraction and scattering)
	42.65.Dr	(Stimulated Raman scattering; CARS)
	42.65.-k	(Nonlinear optics)
	87.64.-t	(Spectroscopic and microscopic techniques in biophysics and medical physics)

Fund: Project supported by the National Basic Research Program of China (Grant No. 2012CB825802), the Major Scientific Instruments Equipment Development of China (Grant No. 2012YQ15009203), the National Natural Science Foundation of China (Grant Nos. 60878053 and 11004136), and the State Key Laboratory of Precision Measurement Technology and Instruments, Tsinghua University, China (Grant No. DL12-01).

Corresponding Authors: Chen Dan-Ni,Niu Han-Ben
E-mail: dannyc007@163.com;hbniu@szu.edu.cn

About author: 42.25.Fx; 42.65.Dr; 42.65.-k; 87.64.-t

Cite this article:

Liu Wei (刘伟), Liu Shuang-Long (刘双龙), Chen Dan-Ni (陈丹妮), Niu Han-Ben (牛憨笨) Analysis of detection limit to time-resolved coherent anti-Stokes Raman scattering nanoscopy 2014 Chin. Phys. B 23 104202


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Analysis of detection limit to time-resolved coherent anti-Stokes Raman scattering nanoscopy

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