A mathematical model of a P53 oscillation network triggered by DNA damage

doi:10.1088/1674-1056/19/4/040506

Abstract Taking the interaction between a DNA damage repair module, an ATM module, and a P53--MDM2 oscillation module into account, this paper presents a mathematical model of a P53 oscillation network triggered by a DNA damage signal in individual cells. The effects of the DNA damage signal and the delay time of P53-induced MDM2 expression on the behaviours of the P53 oscillation network are studied. In the oscillatory state of the P53--MDM2 oscillator, it is found that the pulse number of P53--P oscillation increases with the increase of the initial DNA damage signal, whereas the amplitude and the period of P53--P oscillation are fixed for different initial DNA damage signals, and the period numbers of P53--P oscillations decrease with the increase of time delay of MDM2 expression induced by P53. These theoretical predictions are consistent with previous experimental results. The combined negative feedback of P53--MDM2 with the time delay of P53-induced MDM2 expression causes oscillation behaviour in the P53 network.

Keywords: P53 oscillation network DNA damage signal time delay kinetic model

Received: 07 January 2009
Revised: 04 March 2009
Accepted manuscript online:

PACS:	87.14.G-	(Nucleic acids)
	87.15.K-	(Molecular interactions; membrane-protein interactions)
	87.17.-d	(Cell processes)
	87.14.E-	(Proteins)

Fund: Project supported by the National Natural Science Foundation of China (Grant No.~10875049), the Key Project of Chinese Ministry of Education (Grant No.~108096), and the Programme of Introducing Talents of Discipline to Universities (Grant No.~B08033).

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Xia Jun-Feng(夏俊峰) and Jia Ya(贾亚) A mathematical model of a P53 oscillation network triggered by DNA damage 2010 Chin. Phys. B 19 040506

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A mathematical model of a P53 oscillation network triggered by DNA damage

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