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Chinese Physics, 2003, Vol. 12(2): 226-230    DOI: 10.1088/1009-1963/12/2/320
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Interactions between DNA and histones- a dynamic process of nucleosome formation

Li Wei (李伟)ab, Wang Peng-Ye (王鹏业)a, Dou Shuo-Xing (窦硕星)a, Tong Pei-Qing (童培庆)b
a Laboratory of Soft Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100080, China; b Department of Physics, Nanjing Normal University, Nanjing 210097, China
Abstract  We have studied the dynamic process of interactions between a DNA chain and a histone octamer by numerical simulations. It is found that DNA indeed may wrap around the histone octamer about two turns as in the actual situations. The simulation shows that the interaction potential between DNA and histone is a key factor for the wrapping of DNA, and the temperature is also an important parameter in the process.
Keywords:  DNA      histone      nucleosome      interaction  
Received:  13 September 2002      Revised:  14 October 2002      Accepted manuscript online: 
PACS:  87.16.Sr (Chromosomes, histones)  
  87.15.By  
  87.15.Kg  
  87.15.He  
  87.14.Gg  
  87.10.+e  
Fund: Project supported by the National Natural Science Foundation of China (Grant No 60025516).

Cite this article: 

Li Wei (李伟), Wang Peng-Ye (王鹏业), Dou Shuo-Xing (窦硕星), Tong Pei-Qing (童培庆) Interactions between DNA and histones- a dynamic process of nucleosome formation 2003 Chinese Physics 12 226

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