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Stability of focal adhesion enhanced by its inner force fluctuation |
Mao Zhi-Xiu (毛志秀), Chen Xiao-Feng (陈笑风), Chen Bin (陈彬) |
Department of Engineering Mechanics, Zhejiang University, Hangzhou 310027, China |
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Abstract Cells actively sense and respond to mechanical signals from the extracellular matrix through focal adhesions. By representing a single focal adhesion as a cluster of slip bonds, it has been demonstrated that the cluster often became unstable under fluctuated forces. However, an unusual case was also reported, where the stability of the cluster might be substantially enhanced by a fluctuated force with a relatively low fluctuation frequency and high fluctuation amplitude. Such an observation cannot be explained by the conventional fracture theory of fatigue. Here, we intensively investigate this intriguing observation by carrying out systematic parametric studies. Our intensive simulation results indicate that stability enhancement of this kind is in fact quite robust, which can be affected by the stochastic features of a single bond and the profile of the fluctuated forces such as the average value of bond force. We then suggest that the fluctuation of traction force within a focal adhesion might enhance its stability in a certain way.
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Received: 22 January 2015
Revised: 27 March 2015
Accepted manuscript online:
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PACS:
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87.17.Rt
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(Cell adhesion and cell mechanics)
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87.15.km
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(Protein-protein interactions)
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87.15.La
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(Mechanical properties)
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87.15.Ya
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(Fluctuations)
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Fund: Project supported by the National Natural Science Foundation of China (Grant No. 11372279). |
Corresponding Authors:
Chen Xiao-Feng, Chen Bin
E-mail: chenxiaofeng@zju.edu.cn;chenb6@zju.edu.cn
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Cite this article:
Mao Zhi-Xiu (毛志秀), Chen Xiao-Feng (陈笑风), Chen Bin (陈彬) Stability of focal adhesion enhanced by its inner force fluctuation 2015 Chin. Phys. B 24 088702
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