Molecular modeling of oscillating GHz electric field influence on the kinesin affinity to microtubule

doi:10.1088/1674-1056/24/8/080701

Abstract Kinesin is a microtubule-associated motor protein which can respond to the external electric field due to its polarity. Using a molecular dynamics simulation method, the effect of such a field on the affinity of kinesin to the αβ-tubulin is investigated in this study. To consider kinesin affinity, the system is exposed to an electric field of 0.03 V/nm with frequency values of 1, 2,..., 9, and 10 GHz. It is found that the applied electric field can change kinesin affinity to the microtubule. These changes could perturb the normal operation of kinesin, such as the processive motility of kinesin on the microtubule.

Keywords: kinesin affinity oscillating electric field molecular dynamic αβ-tubulin dimer

Received: 24 September 2014
Revised: 14 March 2015
Accepted manuscript online:

PACS:	07.05.Tp	(Computer modeling and simulation)
	76.60.-k	(Nuclear magnetic resonance and relaxation)
	87.15.R-	(Reactions and kinetics)
	87.10.Tf	(Molecular dynamics simulation)

Corresponding Authors: A. Lohrasebi
E-mail: lohrasebi@nano.ipm.ac.ir

Cite this article:

H. R. Saeidi, S. S. Setayandeh, A. Lohrasebi Molecular modeling of oscillating GHz electric field influence on the kinesin affinity to microtubule 2015 Chin. Phys. B 24 080701

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Molecular modeling of oscillating GHz electric field influence on the kinesin affinity to microtubule

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