|
|
Controlling intracellular Ca2+ spiral waves by the local agonist in the cell membrane |
Qiu Kang(仇康)a), Tang Jun(唐军)b)† , Ma Jun(马军)c), and Luo Ji-Ming(罗继明)b) |
a Department of Mathematics and Physics, Xuzhou Medical College, Xuzhou 221004, China; b College of Science, China University of Mining and Technology, Xuzhou 221008, China; c Department of Physics, Lanzhou University of Technology, Lanzhou 730050, China |
|
|
Abstract A modified spatially extended Tang--Othmer Ca2+ model is used to study intracellular Ca2+ spiral waves numerically. It is found that, as a local stimulation, the local agonist-binding on the cell membrane,which enhances the local concentration of the messenger molecule inositol 1,4,5-trisphosphate(IP3), can influence the dynamics of the spiral waves. 1) Strong enough stimuli can change the spiral wave from a meandering to a rigidly rotating one. 2) On the other hand, strong enough stimuli can suppress the spiral wave from the system. It provides the theoretical clue for controlling the spiral waves by stimulating the cell membrane.
|
Received: 30 July 2009
Revised: 06 September 2009
Accepted manuscript online:
|
PACS:
|
87.16.Uv
|
(Active transport processes)
|
|
87.16.D-
|
(Membranes, bilayers, and vesicles)
|
|
87.16.A-
|
(Theory, modeling, and simulations)
|
|
82.39.Wj
|
(Ion exchange, dialysis, osmosis, electro-osmosis, membrane processes)
|
|
Fund: Project supported by the Xuzhou
Medical College Foundation, China (Grant No.~08kj08). |
Cite this article:
Qiu Kang(仇康), Tang Jun(唐军), Ma Jun(马军), and Luo Ji-Ming(罗继明) Controlling intracellular Ca2+ spiral waves by the local agonist in the cell membrane 2010 Chin. Phys. B 19 030508
|
[1] |
Falcke M and Malchow D 2003 Understanding Calcium Dynamics, Experiments andTheory, Lecture Notes in Physics 623 (Berlin, Heidelberg, NewYork: Berlin)
|
[2] |
Berridge M J 1997 J. Phys. 499 291
|
[3] |
Cornell-Bell A H, Finkbeiner S M, Cooper M S and Smith S J 1990 Science 247 470
|
[4] |
Keener J P and Tyson J J 1986 Physica D 31 307
|
[5] |
Jakubith S, Rotermund H H, Engel W, Oertzen A V and Ertl G 1990 Phys. Rev. Lett.65 3013
|
[5a] |
Rotermund H H, Jakubith S, Oertzen A V and Ertl G 1991 Phys.Rev. Lett. 66 3083
|
[5b] |
Krischer K, Eiswirth M and Ertl G 1992 J. Chem. Phys.96 9161
|
[6] |
Loomis W F 1979 Dev. Biol . 701
|
[6a] |
Tyson J J, Alexander K A, Manoranjan V S and Murray J D 1989 Physica D 34 193
|
[7] |
Lechleiter J D, Girard S, Peralta E and Clapham D 1991 Science 252123
|
[7a] |
Lechleiter J D, Girard S, Clapham D and Peralta E 1991 Nature 350 505
|
[8] |
Tang G N Deng M Y Hu B B and Hu G 2008 Phys. Rev. E 77 46217
|
[8a] |
Li B W, Sun L L, Chen B and Ying H P 2007 Chin. Phys. Lett.24 2415
|
[8b] |
Ma J, Ying H P, Pan G W and Pu Z S 2005 Chin. Phys. Lett. 22 2752
|
[9] |
Yuan G Y, Yang S P, Wang G R and Chen S G 2008 Chin. Phys. B 171925
|
[9a] |
Gan Z N, Ma J, Zhang G Y and Chen Y 2008 Chin. Phys. B 17 4047
|
[10] |
Wang B H, Lu Q S, Lü S J and Lang X F 2009 Chin. Phys. B 18 0872
|
[10a] |
Wang P Y, Xie P and Xin H W 2003 Chin. Phys. 12 0674
|
[11] |
Ma J, Chen Y and Jin W Y 2007 Commun. Theor. Phys. 47 675
|
[11a] |
Ma J, Wang C N, Pu Z S and Li Y L 2006 Commun. Theor. Phys.45 1035
|
[11b] |
Yuan G Y, Wang G R and Chen S G 2005 Commun. Theor. Phys. 44 858
|
[12] |
Sun X P, Callamaras N, Marchant J S and Parker I 1998 J. Physiol . 509 67
|
[13] |
Tang J, Jia Y, Ma J and Yi M 2008 Europhys. Lett. 83 68001
|
[13a] |
Tang J, Ma J, Yi M and Jia Y 2008 Chin. Phys. B 17 4100
|
[14] |
Tang Y, Stephenson J L and Othmer H G 1996 Biophys. J. 70246
|
[15] |
Falcke M, Hudson J L, Camacho P and Lechleiter J D 1999 Biophys. J . 77 37
|
[16] |
Falcke M, Or-Guil M and Markus B 2000 Phys. Rev. Lett. 84 4753
|
[17] |
Falcke M 2003 New J. Phys. 5 96
|
[18] |
Dupont G 1998 Am. J. Physiol cell Physiol. 275 C317
|
No Suggested Reading articles found! |
|
|
Viewed |
|
|
|
Full text
|
|
|
|
|
Abstract
|
|
|
|
|
Cited |
|
|
|
|
Altmetric
|
blogs
Facebook pages
Wikipedia page
Google+ users
|
Online attention
Altmetric calculates a score based on the online attention an article receives. Each coloured thread in the circle represents a different type of online attention. The number in the centre is the Altmetric score. Social media and mainstream news media are the main sources that calculate the score. Reference managers such as Mendeley are also tracked but do not contribute to the score. Older articles often score higher because they have had more time to get noticed. To account for this, Altmetric has included the context data for other articles of a similar age.
View more on Altmetrics
|
|
|