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Cholesterol-induced deformation of the gramicidin A channel inhibiting potassium ion binding and transport |
| Pan Xiao(肖盼)1,2, Yu Cao(曹宇)1,2, Jin Zhu(朱瑾)1,2, and Qing Liang(梁清)1,2,† |
1 Center for Statistical and Theoretical Condensed Matter Physics & Department of Physics, Zhejiang Normal University, Jinhua 321004, China;
2 Zhejiang Institute of Photoelectronics & Zhejiang Institute for Advanced Light Source, Zhejiang Normal University, Jinhua 321004, China |
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Abstract Gramicidin A (gA) is a kind of antibiotic peptide produced by bacillus brevis and it can dimerize across lipid bilayers to form a monovalent cation channel. In this work, we investigate the impact of cholesterol in the lipid bilayer on the binding of potassium ions with the gA channel and the transport of the ions across the channel. The results indicate that cholesterol can significantly influence the conformational stability of the gA channel and cause the channel deformation which inhibits the potassium ion binding with the channel and transport across the channel. The work provides some molecular insights into understanding of influence of lipids on the activity of gA channel in both model membranes and plasma membranes of intact cells.
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Received: 04 February 2024
Revised: 26 February 2024
Accepted manuscript online: 13 March 2024
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PACS:
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87.14.ef
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(Peptides)
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87.16.D-
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(Membranes, bilayers, and vesicles)
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87.15.ap
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(Molecular dynamics simulation)
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87.15.K-
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(Molecular interactions; membrane-protein interactions)
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| Fund: Project supported by the National Natural Science Foundation of China (Grant No. 11674287) and the Zhejiang Provincial Natural Science Foundation of China (Grant No. LY19A040009). |
Corresponding Authors:
Qing Liang
E-mail: qliang@zjnu.edu.cn
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Cite this article:
Pan Xiao(肖盼), Yu Cao(曹宇), Jin Zhu(朱瑾), and Qing Liang(梁清) Cholesterol-induced deformation of the gramicidin A channel inhibiting potassium ion binding and transport 2024 Chin. Phys. B 33 058701
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