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Chin. Phys. B, 2017, Vol. 26(2): 024301    DOI: 10.1088/1674-1056/26/2/024301

Study on shock wave-induced cavitation bubbles dissolution process

Huan Xu(许欢)1,2, Peng-Fei Fan(范鹏飞)1, Yong Ma(马勇)3, Xia-Sheng Guo(郭霞生)1, Ping Yang(杨平)2, Juan Tu(屠娟)1, Dong Zhang(章东)1
1 Key Laboratory of Modern Acoustics of the Ministry of Education, Nanjing University, Nanjing 210093, China;
2 National Institute of Metrology, Beijing 100029, China;
3 Institute of Traumatology and Orthopedics, Nanjing University of Chinese Medicine, Nanjing 210023, China

This study investigated dissolution processes of cavitation bubbles generated during in vivo shock wave (SW)-induced treatments. Both active cavitation detection (ACD) and the B-mode imaging technique were applied to measure the dissolution procedure of biSpheres contrast agent bubbles by in vitro experiments. Besides, the simulation of SW-induced cavitation bubbles dissolution behaviors detected by the B-mode imaging system during in vivo SW treatments, including extracorporeal shock wave lithotripsy (ESWL) and extracorporeal shock wave therapy (ESWT), were carried out based on calculating the integrated scattering cross-section of dissolving gas bubbles with employing gas bubble dissolution equations and Gaussian bubble size distribution. The results showed that (i) B-mode imaging technology is an effective tool to monitor the temporal evolution of cavitation bubbles dissolution procedures after the SW pulses ceased, which is important for evaluation and controlling the cavitation activity generated during subsequent SW treatments within a treatment period; (ii) the characteristics of the bubbles, such as the bubble size distribution and gas diffusion, can be estimated by simulating the experimental data properly.

Keywords:  bubble cavitation      shock wave      B-mode imaging      residual bubbles      bubble dissolution  
Received:  10 October 2016      Revised:  14 November 2016      Published:  05 February 2017
PACS:  43.25.Yw (Nonlinear acoustics of bubbly liquids)  
  43.35.Wa (Biological effects of ultrasound, ultrasonic tomography)  
  43.80.+p (Bioacoustics)  

Project partially supported by the National Natural Science Foundation of China (Grant Nos. 81627802, 81473692, 81673995, 11374155, 11574156, 11474001, 11474161, 11474166, and 11674173), Natural Science Foundation of Jiangsu Province, China (Grant No. BK20151007), and the Qing Lan Project of Jiangsu Province, China.

Corresponding Authors:  Juan Tu, Dong Zhang     E-mail:;

Cite this article: 

Huan Xu(许欢), Peng-Fei Fan(范鹏飞), Yong Ma(马勇), Xia-Sheng Guo(郭霞生), Ping Yang(杨平), Juan Tu(屠娟), Dong Zhang(章东) Study on shock wave-induced cavitation bubbles dissolution process 2017 Chin. Phys. B 26 024301

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