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Chin. Phys. B, 2014, Vol. 23(3): 037503    DOI: 10.1088/1674-1056/23/3/037503
Special Issue: TOPICAL REVIEW — Magnetism, magnetic materials, and interdisciplinary research
TOPICAL REVIEW—Magnetism, magnetic materials, and interdisciplinary research Prev   Next  

Magnetic iron oxide nanoparticles:Synthesis and surface coating techniques for biomedical applications

Sun Sheng-Nana, Wei Chaoa, Zhu Zan-Zanb, Hou Yang-Longc, Subbu S Venkatramana, Xu Zhi-Chuana
a School of Materials and Science Engineering, Nanyang Technological University, Singapore 639798, Singapore;
b Department of Chemical Engineering, Worcester Polytechnic Institute, Worcester, MA 01609, United States;
c Department of Materials Science and Engineering, College of Engineering, Peking University, Beijing 100871, China
Abstract  Iron oxide nanoparticles are the most popular magnetic nanoparticles used in biomedical applications due to their low cost, low toxicity, and unique magnetic property. Magnetic iron oxide nanoparticles, including magnetite (Fe3O4) and maghemite (γ-Fe2O3), usually exhibit a superparamagnetic property as their size goes smaller than 20 nm, which are often denoted as superparamagnetic iron oxide nanoparticles (SPIONs) and utilized for drug delivery, diagnosis, therapy, and etc. This review article gives a brief introduction on magnetic iron oxide nanoparticles in terms of their fundamentals of magnetism, magnetic resonance imaging (MRI), and drug delivery, as well as the synthesis approaches, surface coating, and application examples from recent key literatures. Because the quality and surface chemistry play important roles in biomedical applications, our review focuses on the synthesis approaches and surface modifications of iron oxide nanoparticles. We aim to provide a detailed introduction to readers who are new to this field, helping them to choose suitable synthesis methods and to optimize the surface chemistry of iron oxide nanoparticles for their interests.
Keywords:  Fe3O4      γ-Fe2O3      synthesis      surface coating      biomedical application  
Received:  02 January 2014      Accepted manuscript online: 
PACS:  75.47.Lx (Magnetic oxides)  
  75.75.Cd (Fabrication of magnetic nanostructures)  
  61.46.-w (Structure of nanoscale materials)  
  81.16.Be (Chemical synthesis methods)  
Fund: Project supported by Start-up Grant of Nanyang Technological University and Tier 1 Grant of Ministry of Education, Singapore (RGT8/13).
Corresponding Authors:  Subbu S Venkatraman, Xu Zhi-Chuan     E-mail:;

Cite this article: 

Sun Sheng-Nan, Wei Chao, Zhu Zan-Zan, Hou Yang-Long, Subbu S Venkatraman, Xu Zhi-Chuan Magnetic iron oxide nanoparticles:Synthesis and surface coating techniques for biomedical applications 2014 Chin. Phys. B 23 037503

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