Controlling intracellular Ca2+ spiral waves by the local agonist in the cell membrane

doi:10.1088/1674-1056/19/3/030508

Abstract A modified spatially extended Tang--Othmer Ca²⁺ model is used to study intracellular Ca²⁺ spiral waves numerically. It is found that, as a local stimulation, the local agonist-binding on the cell membrane，which enhances the local concentration of the messenger molecule inositol 1,4,5-trisphosphate(IP₃), can influence the dynamics of the spiral waves. 1) Strong enough stimuli can change the spiral wave from a meandering to a rigidly rotating one. 2) On the other hand, strong enough stimuli can suppress the spiral wave from the system. It provides the theoretical clue for controlling the spiral waves by stimulating the cell membrane.

Keywords: spiral wave local stimuli calcium signaling IP₃

Received: 30 July 2009
Revised: 06 September 2009
Accepted manuscript online:

PACS:	87.16.Uv	(Active transport processes)
	87.16.D-	(Membranes, bilayers, and vesicles)
	87.16.A-	(Theory, modeling, and simulations)
	82.39.Wj	(Ion exchange, dialysis, osmosis, electro-osmosis, membrane processes)

Fund: Project supported by the Xuzhou Medical College Foundation, China (Grant No.~08kj08).

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Qiu Kang(仇康), Tang Jun(唐军), Ma Jun(马军), and Luo Ji-Ming(罗继明) Controlling intracellular Ca²⁺ spiral waves by the local agonist in the cell membrane 2010 Chin. Phys. B 19 030508

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Controlling intracellular Ca2+ spiral waves by the local agonist in the cell membrane

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Controlling intracellular Ca²⁺ spiral waves by the local agonist in the cell membrane