Monte Carlo simulation on backward steps of single kinesin molecule

doi:10.1088/1674-1056/17/4/060

Abstract

Abstract Kinesin is a stepping molecular motor travelling along the microtubule. It moves primarily in the plus end direction of the microtubule and occasionally in the minus-end, backward, direction. Recently, the backward steps of kinesin under different loads and temperatures start to attract interests, and the relations among them are revealed. This paper aims to theoretically understand these relations observed in experiments. After introducing a backward pathway into the previous model of the ATPase cycle of kinesin movement, the dependence of the backward movement on the load and the temperature is explored through Monte Carlo simulation. Our results agree well with previous experiments.

Keywords: kinesin backward steps Monte Carlo ATPase cycle

Received: 28 April 2007
Revised: 22 October 2007
Accepted manuscript online:

PACS:	02.70.Uu	(Applications of Monte Carlo methods)
	87.15.A-	(Theory, modeling, and computer simulation)
	87.15.H-	(Dynamics of biomolecules)
	87.16.Ka	(Filaments, microtubules, their networks, and supramolecular assemblies)
	87.16.Nn	(Motor proteins (myosin, kinesin dynein))

Fund: Project supported by the National Natural Science Foundation of China (Grant Nos 10334100 and 10674173).

Cite this article:

Wang Hong(王宏), Zhang Yong(张勇), Dou Shuo-Xing(窦硕星), and Wang Peng-Ye(王鹏业) Monte Carlo simulation on backward steps of single kinesin molecule 2008 Chin. Phys. B 17 1513

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