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Cholesterol-induced deformation of the gramicidin-A channel inhibiting potassium ion binding and transport |
| Pan Xiao(肖盼)1,2, Yu Cao(曹宇)1,2, Jin Zhu(朱瑾)1,2, and Qing Liang(梁清)1,2,† |
1 Center for Statistical and Theoretical Condensed Matter Physics & Department of Physics, Zhejiang Normal University, Jinhua 321004, China;
2 Zhejiang Institute of Photoelectronics & Zhejiang Institute for Advanced Light Source, Zhejiang Normal University, Jinhua 321004, China |
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Abstract Gramicidin A (gA) is a kind of antibiotic peptide produced by bacillus brevis and it can dimerize across lipid bilayers to form a monovalent cation channel. In this work, we investigate the impact of cholesterol in the lipid bilayer on the binding of potassium ions with the gA channel and the transport of the ions across the channel. The results indicate that cholesterol can significantly influence the conformational stability of the gA channel and cause the channel deformation which inhibits the potassium ion binding with the channel and transport across the channel. The work provides some molecular insights into understanding of influence of lipids on the activity of gA channel in both model membranes and plasma membranes of intact cells.
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Received: 04 February 2024
Revised: 26 February 2024
Accepted manuscript online: 13 March 2024
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PACS:
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73.21.La
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(Quantum dots)
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75.10.Pq
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(Spin chain models)
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64.70.Tg
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(Quantum phase transitions)
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| Fund: Project supported by the National Natural Science Foundation of China (Grant No. 11674287) and the Zhejiang Provincial Natural Science Foundation of China (Grant No. LY19A040009). |
Corresponding Authors:
Qing Liang,E-mail:qliang@zjnu.edu.cn
E-mail: qliang@zjnu.edu.cn
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Cite this article:
Pan Xiao(肖盼), Yu Cao(曹宇), Jin Zhu(朱瑾), and Qing Liang(梁清) Cholesterol-induced deformation of the gramicidin-A channel inhibiting potassium ion binding and transport 2024 Chin. Phys. B 33 058701
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[1] Kelkar D A and Chattopadhyay A 2007 Biochim. Biophys. Acta Biomembr. 1768 2011
[2] Veatch W R, Fossel E T and Blout E R 1974 Biochemistry 13 5249
[3] Yang M, Liu S and Zhang C 2023 Curr. Res. Biotechnol. 5 100121
[4] Pavithrra G and Rajasekaran R 2020 Int. J. Pept. Res. Therap. 26 191
[5] Zerfas B L, Joo Y and Gao J 2016 ChemMedChem 11 629
[6] David J M and Rajasekaran A K 2015 J. Kidney. Cancer. VHL 2 15
[7] Moretta A, Scieuzo C, Petrone A M, Salvia R, Manniello M D, Franco A, Lucchetti D, Vassallo A, Vogel H, Sgambato A and Falabella P 2021 Front. Cell. Infect. Microbiol. 11 668632
[8] Haoyang W W, Xiao Q, Ye Z, Fu Y, Zhang D W, Li J, Xiao L, Li Z T and Hou J L 2021 Chem. Commun. 57 1097
[9] Xue Y W, Itoh H, Dan S and Inoue M 2022 Chem. Sci. 13 7482
[10] Chen T, Wang Y, Yang Y, Yu K, Cao X, Su F, Xu H, Peng Y, Hu Y, Qian F and Wang Z 2019 Biol. Res. 52 57
[11] Yan T, Zheng X, Liu S, Zou Y and Liu J 2022 Sci. China Chem. 65 1265
[12] Urry D 1971 Proc. Natl. Acad. Sci. USA 68 672
[13] LoGrasso P, Moll F and Cross T 1988 Biophys. J. 54 259
[14] Killian J A, Prasad K U, Hains D and Urry D W 1988 Biochemistry 27 4848
[15] Zheng S P, Huang L B, Sun Z and Barboiu M 2020 Angew. Chem. Int. Ed. 60 566
[16] Takada Y, Itoh H, Paudel A, Panthee S, Hamamoto H, Sekimizu K and Inoue M 2020 Nat. Commun. 11 4935
[17] Barboiu M, Le Duc Y, Gilles A, Cazade PA, Michau M, Marie Legrand Y, van der Lee A, Coasne B, Parvizi P, Post J and Fyles T 2014 Nat. Commun. 5 4142
[18] Kondrashov O V, Galimzyanov T R, Molotkovsky R J, Batishchev O V and Akimov S A 2020 Membranes 10 368
[19] Sun D, He S, Bennett W F D, Bilodeau C L, Andersen O S, Lightstone F C and Ingólfsson H I 2020 J. Chem. Theory Comput. 17 7
[20] Maer A M, Rusinova R, Providence L L, Ingólfsson H I, Collingwood S A, Lundbæk J A and Andersen O S 2022 Front. Physiol. 13 836789
[21] Kondrashov O V, Galimzyanov T R, Pavlov K V, Kotova E A, Antonenko Y N and Akimov S A 2018 Biophys. J. 115 478
[22] Yoo J and Cui Q 2013 Biophys. J. 104 128
[23] Foreman-Ortiz I U, Liang D, Laudadio E D, Calderin J D, Wu M, Keshri P, Zhang X, Schwartz M P, Hamers R J, Rotello V M, Murphy C J, Cui Q and Pedersen J A 2020 Proc. Natl. Acad. Sci. USA 117 27854
[24] Su Z, Goodall B, Leitch J J and Lipkowski J 2021 Electrochim. Acta 375 137892
[25] Novoderezhkin V I, Rokitskaya T I, Kotova E A and Antonenko Y N 2023 Phys. Chem. Chem. Phys. 25 3752
[26] Partenskii M B, Miloshevsky G V and Jordan P C 2003 J. Chem. Phys. 118 10306
[27] Goforth R L, Chi A K, Greathouse D V, Providence L L, Koeppe R E II and Andersen O S 2003 J. Gen. Physiol. 121 477
[28] Levitan I, Singh D K and Rosenhouse-Dantsker A 2014 Front. Physiol. 5 65
[29] Corradi V, Bukiya A N, Miranda W E, Cui M, Plant L D, Logothetis D E, Tieleman D P, Noskov S Y and Rosenhouse-Dantsker A 2022 Proc. Natl. Acad. Sci. USA 119 e2109431119
[30] Han S, Chu X P, Goodson R, Gamel P, Peng S, Vance J and Wang S Z 2022 Proc. Natl. Acad. Sci. USA 119 e2205420119
[31] Borcik C G, Eason I R, Yekefallah M, Amani R, Han R X, Vanderloop B H and Wylie B J 2022 Angew. Chem. Int. Ed. 61 e202112232
[32] Zakany F, Kovacs T, Panyi G and Varga Z 2020 Biochim. Biophys. Acta Mol. Cell Biol. Lipids 1865 158706
[33] Jin Y P, Liang Q and Tieleman D P 2020 J. Phys. Chem. B 124 3054
[34] Qin X X, Tieleman D P and Liang Q 2022 Biophys. J. 121 2069
[35] Schagina L V, Blasko K, Grinfeldt A E, Korchev Y E and Lev A A 1989 Biochim. Biophys. Acta Biomembr. 978 145
[36] Schagina L V, Korchev Y E, Grinfeldt A E, Lev A A and Blasto K 1992 Biochim. Biophys. Acta Biomembr. 1109 91
[37] Reiter R, Zaitseva E, Baaken G, Halimeh I, Behrends J C and Zumbuehl A 2019 Langmuir 35 14959
[38] Patrick J W, Gamez R C and Russell D H 2016 Biophys. J. 110 1826
[39] Lee J, Cheng X, Swails J M, Yeom M S, Eastman P K, Lemkul J A, Wei S, Buckner J, Jeong J C, Qi Y, Jo S, Pande V S, Case D A, Brooks III C L, Mackerell Jr. A D, Klauda J B and Im W 2016 J. Chem. Theory Comput. 12 405
[40] Jo S, Klauda J B and Im W 2009 Biophys. J. 97 50
[41] Jo S, Kim T, Iyer V G and Im W 2008 J. Comput. Chem. 29 1859
[42] Klauda J B, Venable R M, Freites J A, O’Connor J W, Tobias D J, Mondragon-Ramirez C, Vorobyov I, MacKerell A D and Pastor R W 2010 J. Phys. Chem. B 114 7830
[43] Huang J and MacKerell A D 2013 J. Comput. Chem. 34 2135
[44] Pastor R W and MacKerell A D 2011 J. Phys. Chem. Lett. 2 1526
[45] Van Der Spoel D, Lindahl E, Hess B, Groenhof G, Mark A E and Berendsen H J C 2005 J. Comput. Chem. 26 1701
[46] Abraham M J, Murtola T, Schulz R, Páll S, Smith J C, Hess B and Lindahl E 2015 SoftwareX 1 19
[47] Bussi G, Donadio D and Parrinello M 2007 J. Chem. Phys. 126 014101
[48] Parrinello M and Rahman A 1981 J. Appl. Phys. 52 7182
[49] Hub J S, de Groot B L and van der Spoel D 2010 J. Chem. Theory Comput. 6 3713
[50] Kumar S, Rosenberg J M, Bouzida D, Swendsen R H and Kollman P A 1992 J. Comput. Chem. 13 1011
[51] Zhu F Q and Hummer G 2012 J. Comput. Chem. 33 453
[52] Humphrey W, Dalke A and Schulten K 1996 J. Mol. Graph. 14 33
[53] Michaud-Agrawal N, Denning E J, Woolf T B and Beckstein O 2011 J. Comput. Chem. 32 2319
[54] Olah G A, Huang H W, Liu W H and Wu Y L 1991 J. Mol. Biol. 218 847
[55] Sham S S, Shobana S, Townsley L E, Jordan J B, Fernandez J Q, Andersen O S, Greathouse D V and Hinton J F 2003 Biochemistry 42 1401
[56] Miloshevsky G V and Jordan P C 2006 Structure 14 1241
[57] Huang Z and London E 2016 Chem. Phys. Lipids 199 11 |
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