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Characteristics of cell motility during cell collision |
| Yikai Ma(马一凯)1, Na Li(李娜)2,3,†, and Wei Chen(陈唯)1,‡ |
1 State Key Laboratory of Surface Physics and Department of Physics, Fudan University, Shanghai 200438, China;
2 China National Center for Bioinformation, Beijing 100101, China;
3 National Genomics Data Center, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China |
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Abstract Quantitative examination of cellular motion and intercellullar interactions possesses substantial relevance for both biology and medicine. However, the effects of intercellular interactions during cellular locomotion remain under-explored in experimental research. As such, this study seeks to bridge this research gap, adopting Dictyostelium discoideum (Dicty) cells as a paradigm to investigate variations in cellular motion during reciprocal collisions. We aim to attain a comprehensive understanding of how cell interactions influence cell motion. By observing and processing the motion trajectories of colliding cells under diverse chemical environments, we calculated the diffusion coefficient ($D$) and the persistence time ($\tau$), using mean square displacement. Our analysis of the relationship dynamics between $D$ and $\tau $ prior to the collisions reveals intricate and non-monotonic alterations in cell movements during collisions. By quantitatively scrutinizing the $\tau $ trend, we were able to categorize the cellular responses to interactions under different conditions. Importantly, we ascertained that the effect of cell interactions during collisions in Dicty cells emulates a classical sigmoid function. This discovery suggests that cellular responses might comply with a pattern akin to the Weber-Fechner law.
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Received: 06 November 2023
Revised: 10 November 2023
Accepted manuscript online: 01 December 2023
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PACS:
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87.18.Gh
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(Cell-cell communication; collective behavior of motile cells)
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87.17.Jj
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(Cell locomotion, chemotaxis)
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05.40.Jc
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(Brownian motion)
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05.40.-a
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(Fluctuation phenomena, random processes, noise, and Brownian motion)
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| Fund: Project supported by the National Natural Science Foundation of China (Grant No. 31971183). |
Corresponding Authors:
Na Li, Wei Chen
E-mail: 694526249@qq.com;phchenwei@fudan.edu.cn
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Cite this article:
Yikai Ma(马一凯), Na Li(李娜), and Wei Chen(陈唯) Characteristics of cell motility during cell collision 2024 Chin. Phys. B 33 028702
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