Surface modification of magnetic nanoparticles in biomedicine

doi:10.1088/1674-1056/24/1/014704

Abstract

Progress in surface modification of magnetic nanoparticles (MNPs) is summarized with regard to organic molecules, macromolecules and inorganic materials. Many researchers are now devoted to synthesizing new types of multi-functional MNPs, which show great application potential in both diagnosis and treatment of disease. By employing an ever-greater variety of surface modification techniques, MNPs can satisfy more and more of the demands of medical practice in areas like magnetic resonance imaging (MRI), fluorescent marking, cell targeting, and drug delivery.

Keywords: magnetic nanoparticles surface modification functionalization magnetic resonance imaging

Received: 04 November 2014
Revised: 09 December 2014
Accepted manuscript online:

PACS:	47.63.mh	(Transport processes and drug delivery)
	87.19.lf	(MRI: anatomic, functional, spectral, diffusion)
	87.57.-s	(Medical imaging)
	87.61.-c	(Magnetic resonance imaging)

Fund:

Project supported by the National Natural Science Foundation of China (Grant Nos. 51125001 and 51172005), the Natural Science Foundation of Beijing, China (Grant No. 2122022), the Science Fund for Creative Research Groups of the National Natural Science Foundation of China (Grant No. 81421004), and the Doctoral Program of the Education Ministry of China (Grant No. 20120001110078).

Corresponding Authors: Hou Yang-Long
E-mail: hou@pku.edu.cn

Cite this article:

Chu Xin (储鑫), Yu Jing (余靓), Hou Yang-Long (侯仰龙) Surface modification of magnetic nanoparticles in biomedicine 2015 Chin. Phys. B 24 014704

[1]	Hao R, Xing R J, Xu Z C, Hou Y L, Gao S and Sun S H 2010 Adv. Mater. 22 2729
[2]	Gupta A K and Gupta M 2005 Biomaterials 26 3995
[3]	Gao J H, Gu H W and Xu B 2009 Accounts Chem. Res. 42 1097
[4]	Jun Y W, Seo J W and Cheon A 2008 Accounts Chem. Res. 41 179
[5]	Huang J, Zhong X D,Wang L Y, Yang L L and Mao H 2012 Theranostics 2 86
[6]	Pankhurst Q A, Thanh N T K, Jones S K and Dobson J 2009 J. Phys. D: Appl. Phys. 42 224001
[7]	Koo O M, Rubinstein I and Onyuksel H 2005 Nanomedicine: Nanotechnology, Biology, and Medicine 1 193
[8]	Veiseh O, Sun C, Gunn J, Kohler N, Gabikian P, Lee D, Bhattarai N, Ellenbogen R, Sze R, Hallahan A, Olson J and Zhang M Q 2005 Nano Lett. 5 1003
[9]	Song H T, Choi J S, Huh Y M, Kim S, Jun Y W, Suh J S and Cheon J 2005 J. Am. Chem. Soc. 127 9992
[10]	Ghosh R, Pradhan L, Devi Y P, Meena S S, Tewari R, Kumar A, Sharma S, Gajbhiye N S, Vatsa R K, Pandey B N and Ningthoujam R S 2011 J. Mater. Chem. 21 13388
[11]	Fauconnier N, Pons J N, Roger J and Bee A 1997 J. Colloid Interface Sci. 194 427
[12]	Cao H N, He J, Deng L and Gao X Q 2009 Appl. Surf. Sci. 255 7974
[13]	Yang H H, Masse S, Zhang H, Helary C, Li L F and Coradin T 2014 J. Colloid Interface Sci. 47 1
[14]	Xiong M H, Bao Y, Yang X Z, Wang Y C, Sun B L and Wang J 2012 J. Am. Chem. Soc. 134 4355
[15]	Ahn J, Moon D S and Lee J K 2013 Langmuir 29 14912
[16]	Dong A G, Ye X C, Chen J, Kang Y J, Gordon T, Kikkawa J M and Murray C B 2011 J. Am. Chem. Soc. 133 998
[17]	Yuen A K L, Hutton G A, Masters A F and Maschmeyer T 2012 Dalton Trans. 41 2545
[18]	Amstad E, Gehring A U, Fischer H, Nagaiyanallur V V, Hahner G, Textor M and Reimhult E 2011 J. Phys. Chem. C 115 683
[19]	Amstad E, Gillich T, Bilecka I, Textor M and Reimhult E 2009 Nano Lett. 9 4042
[20]	Hussein-Al-Ali S H, El Zowalaty M E, Hussein M Z, Ismail M, Dorniani D and Webster T J 2014 Inter. J. Nanomedicine 9 351
[21]	Xiao L, Li J, Brougham D F, Fox E K, Feliu N, Bushmelev A, Schmidt A, Mertens N, Kiessling F, Valldor M, Fadeel B and Mathur S 2011 Acs Nano 5 6315
[22]	Cai H D, Li K G, Shen MW,Wen S H, Luo Y, Peng C, Zhang G X and Shi X Y 2012 J. Mater. Chem. 22 15110
[23]	Lee J H, Huh Y M, Jun Y, Seo J, Jang J, Song H T, Kim S, Cho E J, Yoon H G, Suh J S and Cheon J 2007 Nat. Med. 13 95
[24]	Hao R, Yu J, Ge Z G, Zhao L Y, Sheng F G, Xu L L, Li G J and Hou Y L 2013 Nanoscale 5 11954
[25]	Chen Z P, Zhang Y, Zhang S, Xia J G, Liu J W, Xu K and Gu N 2008 Colloids and Surfaces a-Physicochemical and Engineering Aspects 316 210
[26]	Liu Y X, Chen Z P, Gu N and Wang J K 2011 Toxicology Lett. 205 130
[27]	Yantasee W, Hongsirikarn K, Warner C L, Choi D, Sangvanich T, Toloczko M B, Warner M G, Fryxell G E, Addleman R S and Timchalk C 2008 Analyst 133 348
[28]	de Rosales R T M, Tavare R, Glaria A, Varma G, Protti A and Blower P J 2011 Bioconjugate Chem. 22 455
[29]	Xie J, Chen K, Huang J, Lee S, Wang J H, Gao J, Li X G and Chen X Y 2010 Biomaterials 31 3016
[30]	Bertorelle F, Wilhelm C, Roger J, Gazeau F, Menager C and Cabuil V 2006 Langmuir 22 5385
[31]	Zhang Y, Kohler N and Zhang M Q 2002 Biomaterials 23 1553
[32]	Chekina N, Horak D, Jendelova P, Trchova M, Benes M J, Hruby M, Herynek V, Turnovcova K and Sykova E 2011 J. Mater. Chem. 21 7630
[33]	Hilderbrand S A andWeissleder R 2010 Curr. Opin. Chem. Biol. 14 71
[34]	Veiseh O, Gunn J W and Zhang M Q 2010 Adv. Drug Delivery Rev. 62 284
[35]	Santra S, Kaittanis C, Grimm J and Perez J M 2009 Small 5 1862
[36]	Xie J, Lee S and Chen X Y 2010 Adv. Drug Delivery Rev. 62 1064
[37]	Cao C Y, Shen Y Y, Wang J D, Li L and Liang G L 2013 Sci. Rep. 3 1024
[38]	Zhang C, Wangler B, Morgenstern B, Zentgraf H, Eisenhut M, Untenecker H, Kruger R, Huss R, Seliger C, Semmler W and Kiessling F 2007 Langmuir 23 1427
[39]	Pierrat S, Zins I, Breivogel A and Sonnichsen C 2007 Nano Lett. 7 259
[40]	Gupta A K, Naregalkar R R, Vaidya V D and Gupta M 2007 Nanomedicine 2 23
[41]	Cassidy M C, Chan H R, Ross B D, Bhattacharya P K and Marcus C M 2013 Nat. Nanotechnol. 8 363
[42]	Corot C, Robert P, Idee J M and Port M 2006 Adv. Drug Delivery Rev. 58 1471
[43]	Mikhaylova M, Kim D K, Bobrysheva N, Osmolowsky M, Semenov V, Tsakalakos T and Muhammed M 2004 Langmuir 20 2472
[44]	Josephson L, Tung C H, Moore A andWeissleder R 1999 Bioconjugate Chem. 10 186
[45]	Wunderbaldinger P, Josephson L and Weissleder R 2002 Acad. Radiol. 9 S304
[46]	Tassa C, Shaw S Y andWeissleder R 2011 Accounts Chem. Res. 44 842
[47]	Bae K H, Park M, Do M J, Lee N, Ryu J H, Kim G W, Kim C, Park T G and Hyeon T 2012 Acs Nano 6 5266
[48]	Amstad E, Zurcher S, Mashaghi A, Wong J Y, Textor M and Reimhult E 2009 Small 5 1334
[49]	Xie J, Xu C, Kohler N, Hou Y and Sun S 2007 Adv. Mater. 19 3163
[50]	Li X H and Sun Z G 1995 J. Appl. Polymer Sci. 58 1991
[51]	Sandiford L, Phinikaridou A, Protti A, Meszaros L K, Cui X, Yan Y, Frodsham G, Williamson P A, Gaddum N, Botnar R M, Blower P J, Green M A and de Rosales R T M 2013 Acs Nano 7 500
[52]	Cheng K, Peng S, Xu C and Sun S 2009 J. Am. Chem. Soc. 131 10637
[53]	Li L, Jiang W, Luo K, Song H, Lan F, Wu Y and Gu Z 2013 Theranostics 3 595
[54]	Yan M, Sheng T, Gang B, Chuang G and Zhifei D 2013 Biomaterials 34 7706
[55]	Xu C J, Miranda-Nieves D, Ankrum J A, Matthiesen M E, Phillips J A, Roes I, Wojtkiewicz G R, Juneja V, Kultima J R, Zhao W A, Vemula P K, Lin C P, Nahrendorf M and Karp J M 2012 Nano Lett. 12 4131
[56]	Maeng J H, Lee D H, Jung K H, Bae Y H, Park I S, Jeong S, Jeon Y S, Shim C K, Kim W, Kim J, Lee J, Lee Y M, Kim J H, Kim W H and Hong S S 2010 Biomaterials 31 4995
[57]	Kang X, Yang D, Dai Y, Shang M, Cheng Z, Zhang X, Lian H, Ma P a and Lin J 2013 Nanoscale 5 253
[58]	Cao S W and Zhu Y J 2008 J. Phys. Chem. C 112 12149
[59]	Yang X Q, Chen Y H, Yuan R X, Chen G H, Blanco E, Gao J M and Shuai X T 2008 Polymer 49 3477
[60]	Peppas N A, Hilt J Z, Khademhosseini A and Langer R 2006 Adv. Mater. 18 1345
[61]	Kohler N, Fryxell G E and Zhang M Q 2004 J. Am. Chem. Soc. 126 7206
[62]	Fu L, Dravid V P and Johnson D L 2001 Appl. Surf. Sci. 181 173
[63]	Nakanishi T, Masuda Y and Koumoto K 2004 Chem.Mater. 16 3484
[64]	Bull S R, Guler M O, Bras R E, Meade T J and Stupp S I 2005 Nano Lett. 5 1
[65]	Nasongkla N, Bey E, Ren J M, Ai H, Khemtong C, Guthi J S, Chin S F, Sherry A D, Boothman D A and Gao J M 2006 Nano Lett. 6 2427
[66]	Zhu H, Tao J, Wang W, Zhou Y, Li P, Li Z, Yan K, Wu S, Yeung K W K, Xu Z, Xu H and Chu P K 2013 Biomaterials 34 2296
[67]	Kim M J, Jang D H, Lee Y I, Jung H S, Lee H J and Choa Y H 2011 J. Nanosci. Nanotechnol. 11 889
[68]	Mulder W J M, Strijkers G J, van Tilborg G A F, Griffioen A W and Nicolay K 2006 Nmr in Biomedicine 19 142
[69]	Kim D H, Vitol E A, Liu J, Balasubramanian S, Gosztola D J, Cohen E E, Novosad V and Rozhkova E A 2013 Langmuir 29 7425
[70]	Erathodiyil N and Ying J Y 2011 Accounts Chem. Res. 44 925
[71]	Chen Y, Yin Q, Ji X, Zhang S, Chen H, Zheng Y, Sun Y, Qua H, Wang Z, Li Y, Wang X, Zhang K, Zhang L and Shi J 2012 Biomaterials 33 7126
[72]	Liz-Marzan L M, Giersig M and Mulvaney P 1996 Langmuir 12 4329
[73]	Graf C, Vossen D L J, Imhof A and van Blaaderen A 2003 Langmuir 19 6693
[74]	Lu Z Y, Dai J, Song X N, Wang G and Yang W S 2008 Colloid Surf. A-Physicochem. Eng. Asp. 317 450
[75]	Salgueirino-Maceira V, Correa-Duarte M A, Farle M, Lopez-Quintela A, Sieradzki K and Diaz R 2006 Chem. Mater. 18 2701
[76]	Zhou Z H, Xue J M, Wang J, Chan H S O, Yu T and Shen Z X 2002 J. Appl. Phys. 91 6015
[77]	Tie S L, Lee H C, Bae Y S, KimMB, Lee K and Lee C H 2007 Colloid Surf. A-Physicochem. Eng. Asp. 293 278
[78]	Xu Z Z, Wang C C, Yang W L and Fu S K 2005 J. Mater. Sci. 40 4667
[79]	Ma D L, Guan J W, Normandin F, Denommee S, Enright G, Veres T and Simard B 2006 Chem. Mater. 18 1920
[80]	Ding H L, Zhang Y X, Wang S, Xu J M, Xu S C and Li G H 2012 Chem. Mater. 24 4572
[81]	Salgueirino-Maceira V, Correa-DuarteMA, Spasova M, Liz-Marzan L M and Farle M 2006 Adv. Funct. Mater. 16 509
[82]	Chang Q, Zhu L H, Yu C and Tang H Q 2008 J. Luminescence 128 1890
[83]	Deng Y, Qi D, Deng C, Zhang X and Zhao D 2008 J. Am. Chem. Soc. 130 28
[84]	Wang L S, Wu L C, Lu S Y, Chang L L, Teng I T, Yang C M and Ho J A A 2010 Acs Nano 4 4371
[85]	Son S J, Reichel J, He B, Schuchman M and Lee S B 2005 J. Am. Chem. Soc. 127 7316
[86]	Zhang S L, Chu Z Q, Yin C, Zhang C Y, Lin G and Li Q 2013 J. Am. Chem. Soc. 135 5709
[87]	Li G P, Shen B, He N Y, Ma C, Elingarami S and Li Z Y 2011 J. Nanosci. Nanotechnol. 11 10295
[88]	Selvan S T, Tan T T Y, Yi D K and Jana N R 2010 Langmuir 26 11631
[89]	Gu J H, Zhang W and Yang X L 2013 Mater. Lett. 94 8
[90]	Huang W W, Yang X, Zhao S, Zhang M, Hu X L, Wang J and Zhao H T 2013 Analyst 138 6653
[91]	Mahdavi M, Bin A M, Haron M J, Gharayebi Y, Shameli K and Nadi B 2013 J. Inorg. Organomet. Polym. Mater. 23 599
[92]	Pan M R, Sun Y F, Zheng J and YangWL 2013 Acs Appl. Mater. Inter. 5 8351
[93]	Bain C D, Troughton E B, Tao Y T, Evall J, Whitesides GMand Nuzzo R G 1989 J. Am. Chem. Soc. 111 321
[94]	Wang L Y, Luo J, Fan Q, Suzuki M, Suzuki I S, Engelhard M H, Lin Y H, Kim N, Wang J Q and Zhong C J 2005 J. Phys. Chem. B 109 21593
[95]	Bao J, Chen W, Liu T T, Zhu Y L, Jin P Y, Wang L Y, Liu J F, Wei Y G and Li Y D 2007 Acs Nano 1 293
[96]	Xu C J, Wang B D and Sun S H 2009 J. Am. Chem. Soc. 131 4216
[97]	Ramasamy M, Lee S S, Yi D K and Kim K 2014 J. Mater. Chem. B 2 981
[98]	Gong P, Li H M, He X X, Wang K M, Hu J B, Tan W H, Zhang S C and Yang X H 2007 Nanotechnology 18 285604
[99]	Tang D P, Yuan R and Chai Y Q 2006 J. Phys. Chem. B 110 11640
[100]	Jiang J, Gu H W, Shao H L, Devlin E, Papaefthymiou G C and Ying J Y 2008 Adv. Mater. 20 4403
[101]	Chen J, Guo Z, Wang H B, Gong M, Kong X K, Xia P and Chen Q W 2013 Biomaterials 34 571
[102]	Xu Z C, Hou Y L and Sun S H 2007 J. Am. Chem. Soc. 129 8698
[103]	Zhu X, Zhou J, Chen M, Shi M, Feng W and Li F 2012 Biomaterials 33 4618

[1]	Three-dimensional clogging structures of granular spheres near hopper orifice Jing Yang(杨敬), Dianjinfeng Gong(宫殿锦丰), Xiaoxue Wang(汪晓雪), Zhichao Wang(王志超), Jianqi Li(李建奇), Bingwen Hu(胡炳文), and Chengjie Xia(夏成杰). Chin. Phys. B, 2022, 31(1): 014501.
[2]	Enhanced hyperthermia performance in hard-soft magnetic mixed Zn_0.5Co_xFe_2.5-xO₄/SiO₂ composite magnetic nanoparticles Xiang Yu(俞翔, Li-Chen Wang(王利晨, Zheng-Rui Li(李峥睿, Yan Mi(米岩), Di-An Wu(吴迪安), and Shu-Li He(贺淑莉). Chin. Phys. B, 2021, 30(3): 036201.
[3]	High adsorption and separation performance ofCO₂ over N₂ in azo-based (N=N) pillar[6]arene supramolecular organic frameworks Yong-Chao Jiang(姜永超), Gui-Xia Li(李桂霞), Gui-Feng Yu(于桂凤), Juan Wang(王娟), Shu-Lai Huang(黄树来), and Guo-Liang Xu(徐国亮). Chin. Phys. B, 2021, 30(11): 118105.
[4]	Functionalized magnetic nanoparticles for drug delivery in tumor therapy Ruo-Nan Li(李若男), Xian-Hong Da(达先鸿), Xiang Li (李翔), Yun-Shu Lu(陆云姝), Fen-Fen Gu(顾芬芬), and Yan Liu(刘艳). Chin. Phys. B, 2021, 30(1): 017502.
[5]	Effects of dipolar interactions on the magnetic hyperthermia of Zn_0.3Fe_2.7O₄ nanoparticles with different sizes Xiang Yu(俞翔), Yan Mi(米岩), Li-Chen Wang(王利晨), Zheng-Rui Li(李峥睿), Di-An Wu(吴迪安), Ruo-Shui Liu(刘若水), and Shu-Li He(贺淑莉). Chin. Phys. B, 2021, 30(1): 017503.
[6]	Developing cold-resistant high-adhesive electronic substrate for WIMPs detectors at CDEX Yuanyuan Liu(刘圆圆), Jianping Cheng(程建平), Pan Pang(庞盼), Bin Liao(廖斌), Bin Wu(吴彬), Minju Ying(英敏菊), Fengshou Zhang(张丰收), Lin Chen(陈琳), Shasha Lv(吕沙沙), Yandong Liu(刘言东), Tianxi Sun(孙天希). Chin. Phys. B, 2020, 29(4): 045203.
[7]	Second harmonic magnetoacoustic responses of magnetic nanoparticles in magnetoacoustic tomography with magnetic induction Gepu Guo(郭各朴), Ya Gao(高雅), Yuzhi Li(李禹志), Qingyu Ma(马青玉), Juan Tu(屠娟), Dong Zhang(章东). Chin. Phys. B, 2020, 29(3): 034302.
[8]	Evaluating physical changes of iron oxide nanoparticles due to surface modification with oleic acid S Rosales, N Casillas, A Topete, O Cervantes, G Gonz\'alez, J A Paz, and M E Cano†. Chin. Phys. B, 2020, 29(10): 100502.
[9]	Improved dielectric and electro-optical parameters of nematic liquid crystal doped with magnetic nanoparticles Geeta Yadav, Govind Pathak, Kaushlendra Agrahari, Mahendra Kumar, Mohd Sajid Khan, V S Chandel, Rajiv Manohar. Chin. Phys. B, 2019, 28(3): 034209.
[10]	Flexible rGO/Fe₃O₄ NPs/polyurethane film with excellent electromagnetic properties Wei-Qi Yu(余维琪), Yi-Chen Qiu(邱怡宸), Hong-Jun Xiao(肖红君), Hai-Tao Yang(杨海涛), Ge-Ming Wang(王戈明). Chin. Phys. B, 2019, 28(10): 108103.
[11]	Alkyl group functionalization-induced phonon thermal conductivity attenuation in graphene nanoribbons Caiyun Wang(王彩云), Shuang Lu(鲁爽), Xiaodong Yu(于晓东), Haipeng Li(李海鹏). Chin. Phys. B, 2019, 28(1): 016501.
[12]	Effect of particle size distribution on magnetic behavior of nanoparticles with uniaxial anisotropy S Rizwan Ali, Farah Naz, Humaira Akber, M Naeem, S Imran Ali, S Abdul Basit, M Sarim, Sadaf Qaseem. Chin. Phys. B, 2018, 27(9): 097503.
[13]	Quantum spin Hall insulators in chemically functionalized As (110) and Sb (110) films Xiahong Wang(王夏烘), Ping Li(李平), Zhao Ran(冉召), Weidong Luo(罗卫东). Chin. Phys. B, 2018, 27(8): 087305.
[14]	Design of small-scale gradient coils in magnetic resonance imaging by using the topology optimization method Hui Pan(潘辉), Feng Jia(贾峰), Zhen-Yu Liu(刘震宇), Maxim Zaitsev, Juergen Hennig, Jan G Korvink. Chin. Phys. B, 2018, 27(5): 050201.
[15]	Performance study of aluminum shielded room for ultra-low-field magnetic resonance imaging based on SQUID: Simulations and experiments Bo Li(李波), Hui Dong(董慧), Xiao-Lei Huang(黄小磊), Yang Qiu(邱阳), Quan Tao(陶泉), Jian-Ming Zhu(朱建明). Chin. Phys. B, 2018, 27(2): 020701.

No Suggested Reading articles found!

Viewed

Full text

Abstract

Cited

Metrics
Related Articles

Surface modification of magnetic nanoparticles in biomedicine

Cite this article:

Online attention