| ELECTROMAGNETISM, OPTICS, ACOUSTICS, HEAT TRANSFER, CLASSICAL MECHANICS, AND FLUID DYNAMICS |
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Retinal axial focusing and multi-layer imaging with a liquid crystal adaptive optics camera |
| Liu Rui-Xue (刘瑞雪)a b, Zheng Xian-Liang (郑贤良)a b c, Li Da-Yu (李大禹)a, Xia Ming-Liang (夏明亮)c, Hu Li-Fa (胡立发)a, Cao Zhao-Liang (曹召良)a, Mu Quan-Quan (穆全全)a, Xuan Li (宣丽)a |
a State Key Lab of Applied Optics, Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, Changchun 130033, China;
b University of Chinese Academy of Sciences, Beijing 100049, China;
c Jiangsu Key Laboratory of Medical Optics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou 215163, China |
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Abstract With the help of adaptive optics (AO) technology, cellular level imaging of living human retina can be achieved. Aiming to reduce distressing feelings and to avoid potential drug induced diseases, we attempted to image retina with dilated pupil and froze accommodation without drugs. An optimized liquid crystal adaptive optics camera was adopted for retinal imaging. A novel eye stared system was used for stimulating accommodation and fixating imaging area. Illumination sources and imaging camera kept linkage for focusing and imaging different layers. Four subjects with diverse degree of myopia were imaged. Based on the optical properties of the human eye, the eye stared system reduced the defocus to less than the typical ocular depth of focus. In this way, the illumination light can be projected on certain retina layer precisely. Since that the defocus had been compensated by the eye stared system, the adopted 512×512 liquid crystal spatial light modulator (LC-SLM) corrector provided the crucial spatial fidelity to fully compensate high-order aberrations. The Strehl ratio of a subject with -8 diopter myopia was improved to 0.78, which was nearly close to diffraction-limited imaging. By finely adjusting the axial displacement of illumination sources and imaging camera, cone photoreceptors, blood vessels and nerve fiber layer were clearly imaged successfully.
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Received: 09 December 2013
Revised: 10 February 2014
Accepted manuscript online:
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PACS:
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42.70.Df
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(Liquid crystals)
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42.68.Wt
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(Remote sensing; LIDAR and adaptive systems)
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42.66.Ew
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(Physiology of eye; optic-nerve structure and function)
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| Fund: Project supported by the National Natural Science Foundation of China (Grant Nos. 60736042, 1174274, and 1174279) and the Plan for Scientific and Technology Development of Suzhou, China (Grant No. ZXS201001). |
Corresponding Authors:
Xuan Li
E-mail: xuanli@ciomp.ac.cn
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Cite this article:
Liu Rui-Xue (刘瑞雪), Zheng Xian-Liang (郑贤良), Li Da-Yu (李大禹), Xia Ming-Liang (夏明亮), Hu Li-Fa (胡立发), Cao Zhao-Liang (曹召良), Mu Quan-Quan (穆全全), Xuan Li (宣丽) Retinal axial focusing and multi-layer imaging with a liquid crystal adaptive optics camera 2014 Chin. Phys. B 23 094211
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