Difference-frequency ultrasound generation from microbubbles under dual-frequency excitation

doi:10.1088/1674-1056/19/9/094302

Abstract The difference-frequency (DF) ultrasound generated by using parametric effect promises to improve detection depth owing to its low attenuation, which is beneficial for deep tissue imaging. With ultrasound contrast agents infusion, the harmonic components scattered from the microbubbles, including DF, can be generated due to the nonlinear vibration. A theoretical study on the DF generation from microbubbles under the dual-frequency excitation is proposed in formula based on the solution of the RPNNP equation. The optimisation of the DF generation is discussed associated with the applied acoustic pressure, frequency, and the microbubble size. Experiments are performed to validate the theoretical predictions by using a dual-frequency signal to excite microbubbles. Both the numerical and experimental results demonstrate that the optimised DF ultrasound can be achieved as the difference frequency is close to the resonance frequency of the microbubble and improve the contrast-to-tissue ratio in imaging.

Keywords: difference-frequency microbubble dual-frequency excitation parametric effect

Received: 24 November 2009
Revised: 28 March 2010
Accepted manuscript online:

PACS:	4335
	8750C

Fund: Project supported by the National Natural Science Foundation of China (Grant Nos. 10974098 and 10774071), the Natural Science Foundation of Jiangsu Province, China (Grant No. BK2009407), the Doctoral Foundation of Ministry of Education of China (Grant No. 20093207120003), and the National Basic Research Program of China (Grant No. 2010CB732600).

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Ma Qing-Yu(马青玉), Qiu Yuan-Yuan(邱媛媛), Huang Bei(黄蓓), Zhang Dong(章东), and Gong Xiu-Fen(龚秀芬) Difference-frequency ultrasound generation from microbubbles under dual-frequency excitation 2010 Chin. Phys. B 19 094302

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Difference-frequency ultrasound generation from microbubbles under dual-frequency excitation

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