Microstreaming velocity field and shear stress created by an oscillating encapsulated microbubble near a cell membrane

doi:10.1088/1674-1056/23/12/124302

Abstract Sonoporation mediated by microbubbles is being extensively studied as a promising technology to facilitate gene/drug delivery to cells. However, the theoretical study regarding the mechanisms involved in sonoporation is still in its infancy. Microstreaming generated by pulsating microbubble near the cell membrane is regarded as one of the most important mechanisms in the sonoporation process. Here, based on an encapsulated microbubble dynamic model with considering nonlinear rheological effects of both shell elasticity and viscosity, the microstreaming velocity field and shear stress generated by an oscillating microbubble near the cell membrane are theoretically simulated. Some factors that might affect the behaviors of microstreaming are thoroughly investigated, including the distance between the bubble center and cell membrane (d), shell elasticity (χ), and shell viscosity (κ). The results show that (i) the presence of cell membrane can result in asymmetric microstreaming velocity field, while the constrained effect of the membrane wall decays with increasing the bubble-cell distance; (ii) the bubble resonance frequency increases with the increase in d and χ, and the decrease in κ, although it is more dominated by the variation of shell elasticity; and (iii) the maximal microstreaming shear stress on the cell membrane increases rapidly with reducing the d, χ, and κ. The results suggest that microbubbles with softer and less viscous shell materials might be preferred to achieve more efficient sonoporation outcomes, and it is better to have bubbles located in the immediate vicinity of the cell membrane.

Keywords: microstreaming shear stress sonoporation encapsulated microbubbles

Received: 09 May 2014
Revised: 07 June 2014
Accepted manuscript online:

PACS:	43.25.+y	(Nonlinear acoustics)
	43.80.+p	(Bioacoustics)

Fund: Projects supported by the National Basic Research Program, China (Grant No. 2011CB707900), the National Natural Science Foundation of China (Grant Nos. 81127901, 81227004, 81271589, 11374155, 11161120324, 11074123, 11174141, 11274170, 11104140, 11474001, and 11474161), the National High-Tech Research and Development Program, China (Grant No. 2012AA022702), and the Program for New Century Excellent Talents in University of Ministry of Education of China (Grant No. NCET-11-0236).

Corresponding Authors: Tu Juan, Zhang Dong
E-mail: juantu@nju.edu.cn;dzhang@nju.edu.cn

Cite this article:

Wang Li (王莉), Tu Juan (屠娟), Guo Xia-Sheng (郭霞生), Xu Di (许迪), Zhang Dong (章东) Microstreaming velocity field and shear stress created by an oscillating encapsulated microbubble near a cell membrane 2014 Chin. Phys. B 23 124302


[1]	Yang F, Gu Z X, Jin X and Gu N 2013 Chin. Phys. B 22 104301

[2]	Tsivgoulis G and Alexandrov A V 2007 Neurotherapeutics 4 420

[3]	Wang J H, Brayman A A, Reidy M A, Matula T J, Kimmey M B and Crum L A 2005 Ultrasound Med. Biol. 31 553

[4]	Deshpande M C and Prausnitz M R 2007 J. Control Release 118 126

[5]	Mitragotri S 2005 Nat. Rev. Drug Discov. 4 255

[6]	Ferrara K, Pollard R and Borden M 2007 Rev. Biomed. Eng. 9 415

[7]	Van Wamel A, Kooiman K, Harteveld M, Emmer M, ten Cate F J, Versluis M and de Jong N 2006 J. Control Release 112 149

[8]	Yang F, Gu N, Chen D, Xi X, Zhang D, Li Y and Wu J R 2008 J. Control Release 131 205

[9]	Park J, Fan Z and Deng C 2011 J. Biomech. 44 164

[10]	Marmottant P and Hilgenfeldt S 2003 Nature 423 153

[11]	Wu J, Ross J and Chiu J 2002 J. Acoust. Soc. Am. 111 1460

[12]	Wu J R 2002 Ultrasound Med. Biol. 28 125

[13]	Wu J R 2007 Prog. Biophys. Molecul. Biol. 93 363

[14]	Wu J R and Nyborg W L 2008 Adv. Drug. Deliver. Rev. 60 1103

[15]	Novell A, Collis J, Doinikov A A, Ooi A, Manasseh R and Bouakaz A 2011 IEEE International Ultrasonics Symposium Proceedings p. 1482

[16]	Bhatnagar S, Schiffter H and Coussios C 2014 J. Pharmaceut. Sci. 103 1903

[17]	Kooiman K, Vos H, Versluis M and de Jong N 2014 Adv. Drug. Deliver. Rev. 72 28

[18]	Doinikov A and Bouakaz A 2010 J. Acoust. Soc. Am. 128 11

[19]	Kolb J and Nyborg W 1956 J. Acoust. Soc. Am. 28 1237

[20]	Nyborg W L 1958 J. Acoust. Soc. Am. 30 329

[21]	Elder S A 1959 J. Acoust. Soc. Am. 31 54

[22]	Rooney A 1972 J. Acous. Soc. Am. 52 1718

[23]	Lwein P A and Bjorno L 1982 J. Acoust. Soc. Am. 71 728

[24]	Doinikov A A, Zhao S and Dayton P A 2009 Ultrasonics 49 195

[25]	Frinking P J A and de Jong N 1998 Ultrasound Med. Biol. 24 523

[26]	Marmottant P, Vander Meer S, Emmer M, Versluis M, de Jong N, Hilgenfeldt S and Lohse D 2005 J. Acoust. Soc. Am. 118 3499

[27]	Tsiglifis K and Pelekasis N A 2008 J. Acoust. Soc. Am. 123 4059

[28]	Li Q, Matula T J, Tu J, Guo X S and Zhang D 2013 Phys. Med. Biol. 58 985

[29]	Vander A J, Sherman J H and Luciano D S 2001 Human Physiology (New York: McGraw-Hill) p. 38

[30]	Buchner Santos E, Morris J K, Glynos E, Sboros V and Koutsos V 2012 Langmuir 28 5753

[31]	de Jong N and Hoff L 1993 Ultrasonics 31 175

[32]	de Jong N, Cornet R and Lancee C T 1994 Ultrasonics 32 447

[33]	de Jong N, Cornet R and Lancee C T 1994 Ultrasonics 32 455

[34]	Church C C 1995 J. Acoust. Soc. Am. 97 1510

[35]	Chatterjee D and Sarkar K 2003 Ultrasound Med. Biol. 29 1749

[36]	Doinikov A A and Dayton P A 2007 J. Acoust. Soc. Am. 121 3331

[37]	Doinikov A A, Haac J F and Dayton P A 2009 Ultrasonics 49 269

[38]	Tu J, Guan J F, Qiu Y Y and Matula T J 2009 J. Acoust. Soc. Am. 126 2954

[39]	Vander Meer S, Dollet B, Voormolen M, Chin C, Bouakaz A, de Jong N, Versluis M and Lohse D 2007 J. Acoust. Soc. Am. 121 648

[40]	Huang B, Zhang Y L, Zhang D and Gong X F 2010 Chin. Phys. B 19 054302

[1]	Electronic structure & yield strength prediction for dislocation–Mo complex in the γ phase of nickel-based superalloys Feng-Hua Liu(刘凤华), Chong-Yu Wang(王崇愚). Chin. Phys. B, 2017, 26(7): 076104.
[2]	Microflow-induced shear stress on biomaterial wall by ultrasound-induced encapsulated microbubble oscillation Hu Ji-Wen (胡继文), Qian Sheng-You (钱盛友), Sun Jia-Na (孙佳娜), Lü Yun-Bin (吕云宾), Hu Ping (胡苹). Chin. Phys. B, 2015, 24(9): 094301.
[3]	Analytical investigation on mean and turbulent velocity fields of a plane jet Mi Jian-Chun(米建春) and Feng Bao-Ping(冯宝平) . Chin. Phys. B, 2011, 20(7): 074701.
[4]	Micro thermal shear stress sensor based on vacuum anodic bonding and bulk-micromachining Yi Liang(易亮), Ou Yi(欧毅), Shi Sha-Li(石莎莉), Ma Jin(马瑾), Chen Da-Peng(陈大鹏), and Ye Tian-Chun(叶甜春) . Chin. Phys. B, 2008, 17(6): 2130-2136.
[5]	Three-dimensional lattice Boltzmann method for simulating blood flow in aortic arch Kang Xiu-Ying(康秀英), Ji Yu-Pin(吉驭嫔), Liu Da-He(刘大禾), and Jin Yong-Juan(金永娟). Chin. Phys. B, 2008, 17(3): 1041-1049.
[6]	Polar molecule dominated electrorheological effect Lu Kun-Quan(陆坤权), Shen Rong(沈容), Wang Xue-Zhao(王学昭), Sun Gang(孙刚), Wen Wei-Jia(温维佳), and Liu Ji-Xing(刘寄星). Chin. Phys. B, 2006, 15(11): 2476-2480.
[7]	ANALYSIS OF PARTICLE-PARTICLE FORCES IN ELECTRORHEOLOGICAL FLUIDS Zhao He-ping (赵鹤平), Liu Zheng-you (刘正猷), Liu You-yan (刘有延). Chin. Phys. B, 2001, 10(1): 35-39.

No Suggested Reading articles found!

Viewed

Full text

Abstract

Cited

Metrics
Related Articles

Microstreaming velocity field and shear stress created by an oscillating encapsulated microbubble near a cell membrane

Cite this article:

Online attention