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Chin. Phys. B, 2021, Vol. 30(1): 017502    DOI: 10.1088/1674-1056/abb3e6
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Functionalized magnetic nanoparticles for drug delivery in tumor therapy

Ruo-Nan Li(李若男)1, Xian-Hong Da(达先鸿)1, Xiang Li (李翔)1,†, Yun-Shu Lu(陆云姝)2, Fen-Fen Gu(顾芬芬)3, and Yan Liu(刘艳)3
1 School of Materials Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China; 2 Department of General Surgery, Xinhua Hospital, Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China; 3 Department of Pharmacy, Xinhua Hospital, Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China
Abstract  The side effects of chemotherapy are mainly the poor control of drug release. Magnetic nanoparticles (MNPs) have super-paramagnetic behaviors which are preferred for biomedical applications such as in targeted drug delivery, besides, in magnetic recording, catalysis, and others. MNPs, due to high magnetization response, can be manipulated by the external magnetic fields to penetrate directly into the tumor, thus they can act as ideal drug carriers. MNPs also play a crucial role in drug delivery system because of their high surface-to-volume ratio and porosity. The drug delivery in tumor therapy is related to the sizes, shapes, and surface coatings of MNPs as carriers. Therefore, in this review, we first summarize the effects of the sizes, shapes, and surface coatings of MNPs on drug delivery, then discuss three types of drug release systems, i.e., pH-controlled, temperature-controlled, and magnetic-controlled drug release systems, and finally compare the principle of passive drug release with that of active drug release in tumor therapy.
Keywords:  magnetic nanoparticles      tumor      drug carriers      targeted therapy  
Revised:  28 August 2020      Published:  23 December 2020
PACS:  75.47.Lx (Magnetic oxides)  
  75.90.+w (Other topics in magnetic properties and materials)  
Fund: Project supported by the National Natural Science Foundation of China (Grant Nos. 52072245, 61771092, and 81702588) and the Natural Science Foundation of Shanghai, China (Grant No. 17ZR1419700).
Corresponding Authors:  Corresponding author. E-mail: xiangli@usst.edu.cn   

Cite this article: 

Ruo-Nan Li(李若男), Xian-Hong Da(达先鸿), Xiang Li (李翔), Yun-Shu Lu(陆云姝), Fen-Fen Gu(顾芬芬), and Yan Liu(刘艳) Functionalized magnetic nanoparticles for drug delivery in tumor therapy 2021 Chin. Phys. B 30 017502

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