Magnetic nanoparticle-based cancer therapy

doi:10.1088/1674-1056/22/2/027506

Abstract Nanoparticles (NPs) with easily modified surfaces have been playing an important role in biomedicine. As cancer is one of the major causes of death, tremendous efforts have been devoted to advance the methods of cancer diagnosis and therapy. Recently, magnetic nanoparticles (MNPs) that are responsive to a magnetic field have shown great promise in cancer therapy. Compared with traditional cancer therapy, magnetic field triggered therapeutic approaches can treat cancer in an unconventional but more effective and safer way. In this review, we will discuss the recent progress in cancer therapies based on MNPs, mainly including magnetic hyperthermia, magnetic specific targeting, magnetically controlled drug delivery, magnetofection, and magnetic switches for controlling cell fate. Some recently developed strategies such as magnetic resonance imaging (MRI) monitoring cancer therapy and magnetic tissue engineering are also addressed.

Keywords: magnetic nanoparticles cancer therapy hyperthermia drug delivery targeting magnetic resonance imaging

Received: 31 December 2012
Accepted manuscript online:

PACS:	75.75.c
	87.85.Qr	(Nanotechnologies-design)
	87.85.J
	87.61.c

Fund: Project supported by the National Natural Science Foundation of China (Grant Nos. 51125001, 51172005, and 90922033), the Research Fellowship for International Young Scientists of the National Natural Science Foundation of China (Grant No. 51250110078), the Doctoral Program of the Education Ministry of China (Grant No. 20120001110078), and PKU COE-Health Science Center Seed Fund.

Corresponding Authors: Hou Yang-Long
E-mail: hou@pku.edu.cn

Cite this article:

Yu Jing (余靓), Huang Dong-Yan (黄冬雁), Muhammad Zubair Yousaf, Hou Yang-Long (侯仰龙), Gao Song (高松) Magnetic nanoparticle-based cancer therapy 2013 Chin. Phys. B 22 027506

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