Intrinsic noise analysis and stochastic simulation on transforming growth factor beta signal pathway

doi:10.1088/1674-1056/19/10/108202

Abstract A typical biological cell lives in a small volume at room temperature; the noise effect on the cell signal transduction pathway may play an important role in its dynamics. Here, using the transforming growth factor-β signal transduction pathway as an example, we report our stochastic simulations of the dynamics of the pathway and introduce a linear noise approximation method to calculate the transient intrinsic noise of pathway components. We compare the numerical solutions of the linear noise approximation with the statistic results of chemical Langevin equations, and find that they are quantitatively in agreement with the other. When transforming growth factor-β dose decreases to a low level, the time evolution of noise fluctuation of nuclear Smad2–Smad4 complex indicates the abnormal enhancement in the transient signal activation process.

Keywords: transforming growth factor-β noise chemical Langevin equation linear noise approximation

Received: 21 April 2010
Revised: 10 June 2010
Accepted manuscript online:

PACS:	02.50.Ey	(Stochastic processes)
	87.15.N-	(Properties of solutions of macromolecules)
	87.15.Ya	(Fluctuations)
	87.16.A-	(Theory, modeling, and simulations)
	87.16.Xa	(Signal transduction and intracellular signaling)

Fund: Project supported by the National Natural Science Foundation of China (Grant No. 10721403), and the National Basic Research Program of China (Grant No. 2009CB918500).

Cite this article:

Wang Lu(王路) and Ouyang Qi(欧阳颀) Intrinsic noise analysis and stochastic simulation on transforming growth factor beta signal pathway 2010 Chin. Phys. B 19 108202

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Intrinsic noise analysis and stochastic simulation on transforming growth factor beta signal pathway

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