Numerical study of IP3-induced Ca2+ spiral pattern evolution
Tang Jun (唐 军)ab, Ma Jun (马 军)bc, Yi Ming (易 鸣)b, Jia Ya (贾 亚)c
a College of Science, China University of Mining and Technology, Xuzhou 221008, China; bDepartment of Physics and Institute of Biophysics, Huazhong Normal University, Wuhan 430079, China; c Department of Physics, Lanzhou University of Technology, Lanzhou 730050, China
Abstract The effect of change in concentration of messenger molecule inositol 1,4,5-trisphosphate (IP$_{3})$ on intracellular Ca$^{2 + }$spiral pattern evolution is studied numerically. The results indicate that when the IP$_{3}$ concentration decreases from 0.27 $\mu $M, a physiologically reasonable value, to different values, the spiral centre drifts to the edge of the medium and disappears for a small enough IP$_{3}$ concentration. The instability of spiral pattern can be understood in terms of excitability-change controlled by the IP$_{3}$ concentration. On the other hand, when the IP$_{3}$ concentration increases from 0.27 $\mu $M, a homogeneous area with a high Ca$^{2 + }$ concentration emerges and competes with the spiral pattern. A high enough IP$_{3}$ concentration can lead the homogeneous area to occupy the whole medium. The instability of spiral pattern is ascribed to the change in stability of a stationary state with a high Ca$^{2 + }$ concentration.
Received: 19 May 2008
Revised: 13 June 2008
Accepted manuscript online:
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