Computational and experimental investigations of a microfluidic mixer for efficient iodine extraction using carbon tetrachloride enhanced with gas bubbles

doi:10.1088/1674-1056/acf03f

Abstract Numerous studies have been conducted on microfluidic mixers in various microanalysis systems, which elucidated the manipulation and control of small fluid volumes within microfluidic chips. These studies have demonstrated the ability to control fluids and samples precisely at the microscale. Microfluidic mixers provide high sensitivity for biochemical analysis due to their small volumes and high surface-to-volume ratios. A promising approach in drug delivery is the rapid microfluidic mixer-based extraction of elemental iodine at the micro level, demonstrating the versatility and the potential to enhance diagnostic imaging and accuracy in targeted drug delivery. Micro-mixing inside microfluidic chips plays a key role in biochemical analysis. The experimental study describes a microfluidic mixer for extraction of elemental iodine using carbon tetrachloride with a gas bubble mixing process. Gas bubbles are generated inside the microcavity to create turbulence and micro-vortices resulting in uniform mixing of samples. The bubble mixing of biochemical samples is analyzed at various pressure levels to validate the simulated results in computational fluid dynamics (CFD). The experimental setup includes a high-resolution camera and an air pump to observe the mixing process and volume at different pressure levels with time. The bubble formation is controlled by adjusting the inert gas flow inside the microfluidic chip. Microfluidic chip-based gas bubble mixing effects have been elaborated at various supplied pressures.

Keywords: microfluidic mixer iodine extraction CFD simulation micro-mixing properties

Received: 07 July 2023
Revised: 28 July 2023
Accepted manuscript online: 15 August 2023

PACS:	47.55.Ca	(Gas/liquid flows)
	47.55.D-	(Drops and bubbles)
	47.11.-j	(Computational methods in fluid dynamics)

Fund: Project supported by the National Natural Science Foundation of China (Grant No. 51175101). The authors would also like to acknowledge the help from other HIT Fluid and Flow Group members.

Corresponding Authors: Li Songjing
E-mail: lisongjing@hit.edu.cn

Cite this article:

Siddique Muhammad Kashif, Sun Lin(孙林), and Li Songjing(李松晶) Computational and experimental investigations of a microfluidic mixer for efficient iodine extraction using carbon tetrachloride enhanced with gas bubbles 2023 Chin. Phys. B 32 114702

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Computational and experimental investigations of a microfluidic mixer for efficient iodine extraction using carbon tetrachloride enhanced with gas bubbles

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