Wang Hong-Li(王宏利)a)b)c), Fu Zheng-Ping(傅正平)a), Xu Xin-Hang(徐昕航)a), and Ouyang Qi(欧阳颀)a)b)c)†
a State Key Laboratory for Mesoscopic Physics, School of Physics, Peking University, Beijing 100871, China; b The Beijing-Hong Kong-Singapore Joint Center for Nonlinear and Complex Systems (PKU); cCenter for Theoretical Biology, Peking University,Beijing 100871, China
Abstract We report stochastic simulations of the yeast mating signal transduction pathway. The effects of intrinsic and external noise, the influence of cell-to-cell difference in the pathway capacity, and noise propagation in the pathway have been examined. The stochastic temporal behaviour of the pathway is found to be robust to the influence of inherent fluctuations, and intrinsic noise propagates in the pathway in a uniform pattern when the yeasts are treated with pheromones of different stimulus strengths and of varied fluctuations. In agreement with recent experimental findings, extrinsic noise is found to play a more prominent role than intrinsic noise in the variability of proteins. The occurrence frequency for the reactions in the pathway are also examined and a more compact network is obtained by dropping most of the reactions of least occurrence.
Received: 31 July 2008
Revised: 03 September 2008
Accepted manuscript online:
Fund: Project supported by
the National Natural Science Foundation of China (Grant No 10774008)
and National Key Basic Research Program of China (Grant Nos
2007CB814800 and 2006CB910706). Fu and Xu thank the support of the
National Funds for Fostering Talents i
Cite this article:
Wang Hong-Li(王宏利), Fu Zheng-Ping(傅正平), Xu Xin-Hang(徐昕航), and Ouyang Qi(欧阳颀) Stochasticity in the yeast mating pathway 2009 Chin. Phys. B 18 2082
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