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Chin. Phys. B, 2017, Vol. 26(9): 098102    DOI: 10.1088/1674-1056/26/9/098102
INTERDISCIPLINARY PHYSICS AND RELATED AREAS OF SCIENCE AND TECHNOLOGY Prev   Next  

Silicon quantum dots delivered phthalocyanine for fluorescence guided photodynamic therapy of tumor

Jiao-Jiao Liu(刘娇娇)1, Qi Chang(常琪)1, Mei-Mei Bao(鲍美美)1, Bing Yuan(元冰)1, Kai Yang(杨恺)1, Yu-Qiang Ma(马余强)1,2
1 Center for Soft Condensed Matter Physics and Interdisciplinary Research, College of Physics, Optoelectronics and Energy, Soochow University, Suzhou 215006, China;
2 National Laboratory of Solid State Microstructures and Department of Physics, Nanjing University, Nanjing 210093, China
Abstract  

Imaging-guided cancer therapy provides a simultaneous tumor imaging and treatment, which helps to eliminate the excessive toxicity to the healthy tissues. For this purpose, multifunctional probes capable of both imaging and curing are needed. In this work, we synthesize water-soluble silicon quantum dots (Si QDs) smaller than 5 nm. Such Si QDs are used for delivering the hydrophobic drug phthalocyanine (Pc). The as-prepared Si/Pc nanocomposite particles show efficient transmembrane delivery into cells and feasible biocompatibility. Moreover, these composite particles emit dual-channel fluorescence signals even after cellular internalization and demonstrate robust photostability in the Si channel. More interestingly, the Si/Pc composite particles show efficient photodynamic therapy effects against tumors both in vitro and in vivo.

Keywords:  silicon quantum dot      drug delivery      photodynamic therapy  
Received:  04 May 2017      Revised:  18 May 2017      Accepted manuscript online: 
PACS:  81.07.-b (Nanoscale materials and structures: fabrication and characterization)  
  62.23.-c (Structural classes of nanoscale systems)  
Fund: 

Project supported by the National Natural Science Foundation of China (Grant Nos. 21374074, 21422404, and U1532108) and the Undergraduate Training Program for Innovation and Entrepreneurship of Soochow University, China (Grant No. 2016xj010).

Corresponding Authors:  Bing Yuan, Kai Yang     E-mail:  yuanbing@suda.edu.cn;yangkai@suda.edu.cn

Cite this article: 

Jiao-Jiao Liu(刘娇娇), Qi Chang(常琪), Mei-Mei Bao(鲍美美), Bing Yuan(元冰), Kai Yang(杨恺), Yu-Qiang Ma(马余强) Silicon quantum dots delivered phthalocyanine for fluorescence guided photodynamic therapy of tumor 2017 Chin. Phys. B 26 098102

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