INTERDISCIPLINARY PHYSICS AND RELATED AREAS OF SCIENCE AND TECHNOLOGY |
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Silicon quantum dots delivered phthalocyanine for fluorescence guided photodynamic therapy of tumor |
Jiao-Jiao Liu(刘娇娇)1, Qi Chang(常琪)1, Mei-Mei Bao(鲍美美)1, Bing Yuan(元冰)1, Kai Yang(杨恺)1, Yu-Qiang Ma(马余强)1,2 |
1 Center for Soft Condensed Matter Physics and Interdisciplinary Research, College of Physics, Optoelectronics and Energy, Soochow University, Suzhou 215006, China;
2 National Laboratory of Solid State Microstructures and Department of Physics, Nanjing University, Nanjing 210093, China |
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Abstract Imaging-guided cancer therapy provides a simultaneous tumor imaging and treatment, which helps to eliminate the excessive toxicity to the healthy tissues. For this purpose, multifunctional probes capable of both imaging and curing are needed. In this work, we synthesize water-soluble silicon quantum dots (Si QDs) smaller than 5 nm. Such Si QDs are used for delivering the hydrophobic drug phthalocyanine (Pc). The as-prepared Si/Pc nanocomposite particles show efficient transmembrane delivery into cells and feasible biocompatibility. Moreover, these composite particles emit dual-channel fluorescence signals even after cellular internalization and demonstrate robust photostability in the Si channel. More interestingly, the Si/Pc composite particles show efficient photodynamic therapy effects against tumors both in vitro and in vivo.
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Received: 04 May 2017
Revised: 18 May 2017
Accepted manuscript online:
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PACS:
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81.07.-b
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(Nanoscale materials and structures: fabrication and characterization)
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62.23.-c
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(Structural classes of nanoscale systems)
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Fund: Project supported by the National Natural Science Foundation of China (Grant Nos. 21374074, 21422404, and U1532108) and the Undergraduate Training Program for Innovation and Entrepreneurship of Soochow University, China (Grant No. 2016xj010). |
Corresponding Authors:
Bing Yuan, Kai Yang
E-mail: yuanbing@suda.edu.cn;yangkai@suda.edu.cn
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Cite this article:
Jiao-Jiao Liu(刘娇娇), Qi Chang(常琪), Mei-Mei Bao(鲍美美), Bing Yuan(元冰), Kai Yang(杨恺), Yu-Qiang Ma(马余强) Silicon quantum dots delivered phthalocyanine for fluorescence guided photodynamic therapy of tumor 2017 Chin. Phys. B 26 098102
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[1] |
Ji X, Peng F, Zhong Y, Su Y, Jiang X, Song C, Yang L, Chu B, Lee S T and He Y 2015 Adv. Mater. 27 1029
|
[2] |
Jiang S, Gnanasammandhan M K and Zhang Y 2010 J. R. Soc. Interface 7 3
|
[3] |
Su H Y, Wu C Q, Li D Y and Ai H 2015 Chin. Phys. B 24 127506
|
[4] |
Gao M, Yu F, Lv C, Choo J and Chen L 2017 Chem. Soc. Rev. 46 2237
|
[5] |
Yukawa H and Baba Y 2017 Anal. Chem. 89 2671
|
[6] |
Haque A, Faizi M S, Rather J A and Khan M S 2017 Bioorg. Med. Chem. 25 2017
|
[7] |
Luo Z, Cai K Y, Hu Y, Zhao L, Liu P, Duan L and Yang W H 2011 Angew. Chem. Int. Ed. Engl. 50 640
|
[8] |
Pan L M, He Q J, Liu J N, Chen Y, Ma M, Zhang L L and Shi J L 2012 J. Am. Chem. Soc. 134 5722
|
[9] |
Wang W W, Cheng D, Gong F M, Miao X M and Shuai X T 2012 Adv. Mater. 24 115
|
[10] |
Senapati L, Schrier J and Whaley K B 2004 Nano Lett. 4 2073
|
[11] |
Su Y Y, Peng F, Jiang Z Y, Zhong Y L, Lu Y M, Jiang X X, Huang Q, Fan C H, Lee S T and He Y 2011 Biomaterials 32 5855
|
[12] |
Zhong Y L, Peng F, Bao F, Wang S Y, Ji X Y, Yang L, Su Y Y, Lee S T and He Y 2013 J. Am. Chem. Soc. 135 8350
|
[13] |
Zhong Y, Peng F, Wei X, Zhou Y, Wang J, Jiang X, Su Y, Su S, Lee S T and He Y 2012 Angew. Chem. Int. Ed. Engl. 51 8485
|
[14] |
Park J H, Gu L, Von Maltzahn G, Ruoslahti E, Bhatia S N and Sailor M J 2009 Nat. Mater. 8 331
|
[15] |
Wang Z, Zhang G F, Li B, Chen R Y, Qin C B, Xiao L T and Jia S T 2015 Acta Phys. Sin. 64 247803 (in Chinese)
|
[16] |
Abbasi S, Servatkhah M and Keshtkar M M 2016 Chin. Phys. B 25 087301
|
[17] |
An D Y, Su J G, Li C H and Li J Y 2015 Chin. Phys. B 24 120504
|
[18] |
Liu J, Wang R, Wu S, Yuan B, Bao M, Li J, Dou Y, He Y and Yang K 2017 Nanotechnology 28 135601
|
[19] |
Peng F, Su Y Y, Ji X Y, Zhong Y L, Wei X P and He Y 2014 Biomaterials 35 5188.
|
[20] |
Peng F, Su Y Y, Zhong Y L, Fan C H, Lee S T and He Y 2014 Acc. Chem. Res. 47 612
|
[21] |
Tallury P, Payton K and Santra S 2008 Nanomedicine 3 579
|
[22] |
Li Y, Wang X B, Fan Z Q and Li X J 2014 Chin. Phys. Lett. 31 047801
|
[23] |
Kinnari P J, Hyvönen M L K, Mäkilä E M, Kaasalainen M H, Rivinoja A, Salonen J J, Hirvonen J T, Laakkonen P M and Santos H A 2013 Biomaterials 34 9134
|
[24] |
Hochbaum A I, Gargas D, Hwang Y J and Yang P 2009 Nano Lett. 9 3550
|
[25] |
Shao M, Cheng L, Zhang X, Ma D D and Lee S T 2009 J. Am. Chem. Soc. 131 17738
|
[26] |
Cheng Y, C Samia A, Meyers J D, Panagopoulos I, Fei B and Burda C 2008 J. Am. Chem. Soc. 130 10643
|
[27] |
Ince M, Er O, Ocakoglu K, Lambrecht F Y, Colak S G, Soylu H M, Kayabasi C and Gunduz C 2016 Chem. Biol. Drug Des. 87 224
|
[28] |
Yu C, Meyers J D, Broome A M, Kenney M E, Basilion J P and Burda C 2011 J. Am. Chem. Soc. 133 2583
|
[29] |
Zorlu Y, Dumoulin F, Bouchu D, Ahsen V and Lafont D 2010 Tetrahedron Lett. 51 6615
|
[30] |
Li J, Zhang W D, Hu Z J, Jiang X J, Ngai T, Lo P C, Zhang W and Chen G J 2013 Polym. Chem. 4 782
|
[31] |
Cheng L, He W W, Gong H, Wang C, Chen Q, Cheng Z P and Liu Z 2013 Adv. Funct. Mater. 23 5893
|
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