A new understanding of inert gas narcosis

doi:10.1088/1674-1056/25/1/013602

Abstract

Anesthetics are extremely important in modern surgery to greatly reduce the patient's pain. The understanding of anesthesia at molecular level is the preliminary step for the application of anesthetics in clinic safely and effectively. Inert gases, with low chemical activity, have been found to cause anesthesia for centuries, but the mechanism is unclear yet. In this review, we first summarize the progress of theories about general anesthesia, especially for inert gas narcosis, and then propose a new hypothesis that the aggregated rather than the dispersed inert gas molecules are the key to trigger the narcosis to explain the steep dose-response relationship of anesthesia.

Keywords: cluster inert gas anesthesia narcotic potency

Received: 23 May 2015
Revised: 30 November 2015
Accepted manuscript online:

PACS:	36.40.-c	(Atomic and molecular clusters)
	82.20.Wt	(Computational modeling; simulation)
	87.15.A-	(Theory, modeling, and computer simulation)
	87.50.cf	(Biophysical mechanisms of interaction)

Fund:

Project supported by the Supercomputing Center of Chinese Academy of Sciences in Beijing, China, the Shanghai Supercomputer Center, China, the National Natural Science Foundation of China (Grant Nos. 21273268, 11290164, and 11175230), the Startup Funding from Shanghai Institute of Applied Physics, Chinese Academy of Sciences (Grant No. Y290011011), “Hundred People Project” from Chinese Academy of Sciences, and “Pu-jiang Rencai Project” from Science and Technology Commission of Shanghai Municipality, China (Grant No. 13PJ1410400).

Corresponding Authors: Yi Gao, Haiping Fang
E-mail: gaoyi@sinap.ac.cn;fanghaiping@sinap.ac.cn

Cite this article:

Meng Zhang(张萌), Yi Gao(高嶷), Haiping Fang(方海平) A new understanding of inert gas narcosis 2016 Chin. Phys. B 25 013602

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A new understanding of inert gas narcosis

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