ELECTROMAGNETISM, OPTICS, ACOUSTICS, HEAT TRANSFER, CLASSICAL MECHANICS, AND FLUID DYNAMICS |
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Thermoacoustic assessment of hematocrit changes in human forearms |
Xue Wang(王雪)1,2, Rui Zhao(赵芮)1,2, Yi-Tong Peng(彭亦童)1, Zi-Hui Chi(迟子惠)4, Zhu Zheng(郑铸)1,2, En Li(李恩)1, Lin Huang(黄林)1,2,†, and Hua-Bei Jiang(蒋华北)3,‡ |
1 School of Electronic Science and Engineering(National Exemplary School of Microelectronics), University of Electronic Science and Technology of China, Chengdu 611731, China; 2 Center for Information in Medicine, University of Electronic and Technology of China, Chengdu 611731, China; 3 Department of Medical Engineering, University of South Florida, Tampa FL 33620, USA; 4 School of Optoelectronic Engineering, Chongqing University of Posts and Telecommunications, Chongqing 400065, China |
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Abstract Abnormal hematocrit (Hct) is associated with an increased risk of pre-hypertension and all-cause death in general population, and people with a high Hct value are susceptible to arterial cardiovascular disease and venous thromboembolism. In this study, we report for the first time on the ability of thermoacoustic imaging (TAI) for in vivo evaluating Hct changes in human forearms. In vitro blood samples with different Hct values from healthy volunteers (n=3) were prepared after centrifugation. TAI was performed using these samples in comparison with the direct measurements of conductivity. In vivo TAI was conducted in the forearm of healthy volunteers (n=7) where Hct changes were produced through a vascular occlusion stimulation over a period of time. The results of in vitro blood samples obtained from the 3 healthy subjects show that the thermoacoustic (TA) signals changes due to the variation of blood conductivity are closely related to the changes in Hct. In addition, the in vivo TA signals obtained from the 7 healthy subjects consistently increase in the artery/muscle and decrease in the vein during venous or arterial occlusion because of the changed Hct value in their forearms. These findings suggest that TAI has the potential to become a new tool for monitoring Hct changes for a variety of pre-clinical and clinical applications.
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Received: 04 December 2020
Revised: 17 February 2021
Accepted manuscript online: 24 May 2021
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PACS:
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43.35.Ud
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(Thermoacoustics, high temperature acoustics, photoacoustic effect)
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87.85.Pq
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(Biomedical imaging)
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43.35.Wa
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(Biological effects of ultrasound, ultrasonic tomography)
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Fund: Project supported by the National Natural Science Foundation of China (Grant Nos. 61701076, 82071940, and 62001075). |
Corresponding Authors:
Lin Huang, Hua-Bei Jiang
E-mail: lhuang@uestc.edu.cn;hjiang1@usf.edu
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Cite this article:
Xue Wang(王雪), Rui Zhao(赵芮), Yi-Tong Peng(彭亦童), Zi-Hui Chi(迟子惠), Zhu Zheng(郑铸), En Li(李恩), Lin Huang(黄林), and Hua-Bei Jiang(蒋华北) Thermoacoustic assessment of hematocrit changes in human forearms 2021 Chin. Phys. B 30 094302
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