A nonequilibrium phase transition in immune response
Zhang Wei (张伟)a, Qi An-Shen (漆安慎)b
a Department of System Science, Beijing Normal University, Beijing 100875, China; b Department of Physics, Beijing Normal University, Beijing 100875, China
Abstract The dynamics of immune response correlated to signal transduction in immune thymic cells (T cells) is studied. In particular, the problem of the phosphorylation of the immune-receptor tyrosine-based activation motifs (ITAM) is explored. A nonlinear model is established on the basis of experimental observations. The behaviours of the model can be well analysed using the concepts of nonequilibrium phase transitions. In addition, the Riemann-Hugoniot cusp catastrophe is demonstrated by the model. Due to the application of the theory of nonequilibrium phase transitions, the biological phenomena can be clarified more precisely. The results can also be used to further explain the signal transduction and signal discrimination of an important type of immune T cell.
Received: 11 December 2003
Revised: 04 March 2004
Accepted manuscript online:
Equation of state of LiCoO2 under 30 GPa pressure Yong-Qing Hu(户永清), Lun Xiong(熊伦), Xing-Quan Liu(刘兴泉), Hong-Yuan Zhao(赵红远), Guang-Tao Liu(刘广涛), Li-Gang Bai(白利刚), Wei-Ran Cui(崔巍然), Yu Gong(宫宇), Xiao-Dong Li(李晓东). Chin. Phys. B, 2019, 28(1): 016402.
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