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Chin. Phys. B, 2015, Vol. 24(11): 114301    DOI: 10.1088/1674-1056/24/11/114301
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Enhancement of photoacoustic tomography in the tissue with speed-of-sound variance using ultrasound computed tomography

Cheng Ren-Xiang (程任翔), Tao Chao (陶超), Liu Xiao-Jun (刘晓峻)
Key Laboratory of Modern Acoustics of Ministry of Education, Department of Physics, Nanjing University, Nanjing 210093, China
Abstract  The speed-of-sound variance will decrease the imaging quality of photoacoustic tomography in acoustically inhomogeneous tissue. In this study, ultrasound computed tomography is combined with photoacoustic tomography to enhance the photoacoustic tomography in this situation. The speed-of-sound information is recovered by ultrasound computed tomography. Then, an improved delay-and-sum method is used to reconstruct the image from the photoacoustic signals. The simulation results validate that the proposed method can obtain a better photoacoustic tomography than the conventional method when the speed-of-sound variance is increased. In addition, the influences of the speed-of-sound variance and the fan-angle on the image quality are quantitatively explored to optimize the image scheme. The proposed method has a good performance even when the speed-of-sound variance reaches 14.2%. Furthermore, an optimized fan angle is revealed, which can keep the good image quality with a low cost of hardware. This study has a potential value in extending the biomedical application of photoacoustic tomography.
Keywords:  photoacoustic tomography      speed of sound      ultrasound computed tomography  
Received:  31 May 2015      Revised:  13 July 2015      Accepted manuscript online: 
PACS:  43.35.Ud (Thermoacoustics, high temperature acoustics, photoacoustic effect)  
  43.58.Dj (Sound velocity)  
  43.35.Wa (Biological effects of ultrasound, ultrasonic tomography)  
  43.80.+p (Bioacoustics)  
Fund: Projection supported by the National Basic Research Program of China (Grant No. 2012CB921504), the National Natural Science Foundation of China (Grant Nos. 11422439, 11274167, and 11274171), and the Specialized Research Fund for the Doctoral Program of Higher Education, China (Grant No. 20120091110001).
Corresponding Authors:  Tao Chao, Liu Xiao-Jun     E-mail:  taochao@nju.edu.cn;liuxiaojun@nju.edu.cn

Cite this article: 

Cheng Ren-Xiang (程任翔), Tao Chao (陶超), Liu Xiao-Jun (刘晓峻) Enhancement of photoacoustic tomography in the tissue with speed-of-sound variance using ultrasound computed tomography 2015 Chin. Phys. B 24 114301

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