Treatable focal region modulated by double excitation signal superimposition to realize platform temperature distribution during transcranial brain tumor therapy with high-intensity focused ultrasound

doi:10.1088/1674-1056/27/7/078701

Abstract Recently, the phase compensation technique has allowed the ultrasound to propagate through the skull and focus into the brain. However, the temperature evolution during treatment is hard to control to achieve effective treatment and avoid over-high temperature. Proposed in this paper is a method to modulate the temperature distribution in the focal region. It superimposes two signals which focus on two preset different targets with a certain distance. Then the temperature distribution is modulated by changing triggering time delay and amplitudes of the two signals. The simulation model is established based on an 82-element transducer and computed tomography (CT) data of a volunteer's head. A finite-difference time-domain (FDTD) method is used to calculate the temperature distributions. The results show that when the distances between the two targets respectively are 7.5-12.5 mm on the acoustic axis and 2.0-3.0 mm in the direction perpendicular to the acoustic axis, a focal region with a uniform temperature distribution (64-65 ℃) can be created. Moreover, the volume of the focal region formed by one irradiation can be adjusted (26.8-266.7 mm³) along with the uniform temperature distribution. This method may ensure the safety and efficacy of HIFU brain tumor therapy.

Keywords: high-intensity focused ultrasound (HIFU) transcranial therapy double excitation signal superimposition temperature modulation of focal region

Received: 02 February 2018
Revised: 01 May 2018
Accepted manuscript online:

PACS:	87.50.Y-	(Biological effects of acoustic and ultrasonic energy)
	87.55.Gh	(Simulation)
	87.55.dh	(Tissue response)
	87.55.de	(Optimization)

Fund: Project supported by the National Natural Science Foundation of China (Grant No. 81272495) and the Natural Science Foundation of Tianjin, China (Grant No. 16JC2DJC32200).

Corresponding Authors: Xi-Qi Jian
E-mail: jianxiqi@tmu.edu.cn

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Shi-Hui Chang(常诗卉), Rui Cao(曹睿), Ya-Bin Zhang(张亚斌), Pei-Guo Wang(王佩国), Shi-Jing Wu(吴世敬), Yu-Han Qian(钱宇晗), Xi-Qi Jian(菅喜岐) Treatable focal region modulated by double excitation signal superimposition to realize platform temperature distribution during transcranial brain tumor therapy with high-intensity focused ultrasound 2018 Chin. Phys. B 27 078701

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Treatable focal region modulated by double excitation signal superimposition to realize platform temperature distribution during transcranial brain tumor therapy with high-intensity focused ultrasound

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