Nonlinear response of ultrasound contrast agent microbubbles: From fundamentals to applications

doi:10.1088/1674-1056/25/12/124308

Abstract

Modelling and biomedical applications of ultrasound contrast agent (UCA) microbubbles have attracted a great deal of attention. In this review, we summarize a series of researches done in our group, including (i) the development of an all-in-one solution of characterizing coated bubble parameters based on the light scattering technique and flow cytometry; (ii) a novel bubble dynamic model that takes into consideration both nonlinear shell elasticity and viscosity to eliminate the dependences of bubble shell parameters on bubble size; (iii) the evaluation of UCA inertial cavitation threshold and its relationship with shell parameters; and (iv) the investigations of transfection efficiency and the reduction of cytotoxicity in gene delivery facilitated by UCAs excited by ultrasound exposures.

Keywords: ultrasound contrast agents microbubbles nonlinear response inertial cavitation DNA transfection

Received: 11 May 2016
Revised: 10 July 2016
Accepted manuscript online:

PACS:	43.25.+y	(Nonlinear acoustics)
	43.80.+p	(Bioacoustics)

Fund:

Projects supported by the National Natural Science Foundation of China (Grant Nos. 81127901, 81227004, 11374155, 11274170, 11274176, 11474001, 11474161, 11474166, and 11674173), the National High-Technology Research and Development Program, China (Grant No. 2012AA022702), and Qing Lan Project of Jiangsu Province, China.

Corresponding Authors: Xia-Sheng Guo, Dong Zhang
E-mail: guoxs@nju.edu.cn;dzhang@nju.edu.cn

Cite this article:

Xu-Dong Teng(滕旭东), Xia-Sheng Guo(郭霞生), Juan Tu(屠娟), Dong Zhang(章东) Nonlinear response of ultrasound contrast agent microbubbles: From fundamentals to applications 2016 Chin. Phys. B 25 124308

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Nonlinear response of ultrasound contrast agent microbubbles: From fundamentals to applications

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