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Chin. Phys. B, 2016, Vol. 25(12): 124308    DOI: 10.1088/1674-1056/25/12/124308
SPECIAL TOPIC—Acoustics Prev   Next  

Nonlinear response of ultrasound contrast agent microbubbles: From fundamentals to applications

Xu-Dong Teng(滕旭东), Xia-Sheng Guo(郭霞生), Juan Tu(屠娟), Dong Zhang(章东)
Institute of Acoustics, Key Laboratory of Modern Acoustics(MOE), School of Physics, Nanjing University, Nanjing 210093, China
Abstract  

Modelling and biomedical applications of ultrasound contrast agent (UCA) microbubbles have attracted a great deal of attention. In this review, we summarize a series of researches done in our group, including (i) the development of an all-in-one solution of characterizing coated bubble parameters based on the light scattering technique and flow cytometry; (ii) a novel bubble dynamic model that takes into consideration both nonlinear shell elasticity and viscosity to eliminate the dependences of bubble shell parameters on bubble size; (iii) the evaluation of UCA inertial cavitation threshold and its relationship with shell parameters; and (iv) the investigations of transfection efficiency and the reduction of cytotoxicity in gene delivery facilitated by UCAs excited by ultrasound exposures.

Keywords:  ultrasound contrast agents      microbubbles      nonlinear response      inertial cavitation      DNA transfection  
Received:  11 May 2016      Revised:  10 July 2016      Published:  05 December 2016
PACS:  43.25.+y (Nonlinear acoustics)  
  43.80.+p (Bioacoustics)  
Fund: 

Projects supported by the National Natural Science Foundation of China (Grant Nos. 81127901, 81227004, 11374155, 11274170, 11274176, 11474001, 11474161, 11474166, and 11674173), the National High-Technology Research and Development Program, China (Grant No. 2012AA022702), and Qing Lan Project of Jiangsu Province, China.

Corresponding Authors:  Xia-Sheng Guo, Dong Zhang     E-mail:  guoxs@nju.edu.cn;dzhang@nju.edu.cn

Cite this article: 

Xu-Dong Teng(滕旭东), Xia-Sheng Guo(郭霞生), Juan Tu(屠娟), Dong Zhang(章东) Nonlinear response of ultrasound contrast agent microbubbles: From fundamentals to applications 2016 Chin. Phys. B 25 124308

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