Effect of terahertz pulse on gene expression in human eye cells

doi:10.1088/1674-1056/28/4/048703

Abstract

In recent years, the advances in terahertz applications have stimulated interest in the biological effects associated with this frequency range. We study the gene expression profile in three types of cells exposed to terahertz radiation, i.e., human ARPE-19 retinal pigment epithelial cells, simian virus 40-transformed human corneal epithelial cells, and human MIO-M1 Müller cells. We find that the gene expression in response to heat shock is unaffected, indicating that the minimum temperature increases under controlled environment. The transcriptome sequencing survey demonstrates that 6-hour irradiation with a broadband terahertz source results in specific change in gene expression and also the biological functions that are closely related to these genes. Our results imply that the effect of terahertz radiation on gene expression can last over 15 hours and depends on the type of cell.

Keywords: terahertz radiation eye cells gene expression

Received: 12 October 2018
Revised: 31 January 2019
Accepted manuscript online:

PACS:	87.50.-a	(Effects of electromagnetic and acoustic fields on biological systems)
	87.10.Vg	(Biological information)
	42.62.Be	(Biological and medical applications)
	87.50.up	(Dosimetry/exposure assessment)

Fund:

Project supported by the National Natural Science Foundation of China (Grant Nos. 61675151 and 81570872), the Tianjin Municipal Science and Technology Commission Grants, China (Grant No. 15JCYBJC24900), and the Clinical Research Foundation of Tianjin Medical University Eye Institute, China (Grant No. 16YKJS002).

Corresponding Authors: Ming-Xia He
E-mail: hhmmxx@tju.edu.cn

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Jin-Wu Zhao(赵晋武), Ming-Xia He(何明霞), Li-Jie Dong(东莉洁), Shao-Xian Li(李绍限), Li-Yuan Liu(刘立媛), Shao-Chong Bu(步绍翀), Chun-Mei Ouyang(欧阳春梅), Peng-Fei Wang(王鹏騛), Long-Ling Sun(孙珑玲) Effect of terahertz pulse on gene expression in human eye cells 2019 Chin. Phys. B 28 048703

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Effect of terahertz pulse on gene expression in human eye cells

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