Mechanical activation of DNA transport across single-walled carbon nanotubes

doi:10.1088/1674-1056/adce9b

Abstract We employed molecular dynamics simulations to investigate the directed transport of a double-stranded oligonucleotide (dsDNA) through a single-walled carbon nanotube (SWNT) powered by external mechanical vibrations. It is thermodynamically favorable for dsDNA to adsorb inside the SWNT, and its transport through the nanotube is challenging due to the high energy barrier. However, we demonstrate that mechanical vibrations at specific frequencies can effectively drive the dsDNA through the nanotube based on a ratchet effect. The system is driven away from thermal equilibrium, and the spatial inversion symmetry is broken by mechanical vibrations. This study provides valuable insights into the mechanisms of mechanically activated DNA transport and highlights the potential of using SWNTs as nanoscale conduits for dsDNA delivery in nanobiotechnology and biomedicine.

Keywords: double-stranded oligonucleotide (dsDNA) single-walled carbon nanotube (SWNT) mechanical vibrations ratchet effect

Received: 19 February 2025
Revised: 12 April 2025
Accepted manuscript online: 21 April 2025

PACS:	87.14.gk	(DNA)
	87.15.ap	(Molecular dynamics simulation)
	87.85.Rs	(Nanotechnologies-applications)
	05.40.-a	(Fluctuation phenomena, random processes, noise, and Brownian motion)

Fund: Project supported by the National Natural Science Foundation of China (Grant No. 11875237).

Corresponding Authors: Xiaoyan Zhou, Hangjun Lu
E-mail: zxylu@zjnu.cn;zjlhjun@zjnu.cn

Cite this article:

Junjie Gao(高俊杰), Yichao Wu(吴逸超), Siqi Yu(俞斯棋), Xiaoyan Zhou(周晓艳), and Hangjun Lu(陆杭军) Mechanical activation of DNA transport across single-walled carbon nanotubes 2025 Chin. Phys. B 34 108701

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