Cooperative activation of sodium channels for downgrading the energy efficiency in neuronal information processing

doi:10.1088/1674-1056/ad21f5

Abstract The Hodgkin-Huxley model assumes independent ion channel activation, although mutual interactions are common in biological systems. This raises the problem why neurons would favor independent over cooperative channel activation. In this study, we evaluate how cooperative activation of sodium channels affects the neuron's information processing and energy consumption. Simulations of the stochastic Hodgkin-Huxley model with cooperative activation of sodium channels show that, while cooperative activation enhances neuronal information processing capacity, it greatly increases the neuron's energy consumption. As a result, cooperative activation of sodium channel degrades the energy efficiency for neuronal information processing. This discovery improves our understanding of the design principles for neural systems, and may provide insights into future designs of the neuromorphic computing devices as well as systematic understanding of pathological mechanisms for neural diseases.

Keywords: energy efficiency ion channel noise action potential generation neuronal dynamics

Received: 27 November 2023
Revised: 15 January 2024
Accepted manuscript online: 24 January 2024

PACS:	87.85.dh	(Cells on a chip)
	87.80.-y	(Biophysical techniques (research methods))
	87.18.Gh	(Cell-cell communication; collective behavior of motile cells)
	87.50.cf	(Biophysical mechanisms of interaction)

Fund: This study was supported by the Fundamental Research Funds for the Central Universities (Grant No. lzujbky-2021- 62), the Shanghai Municipal Science and Technology Major Project (Grant No. 2018SHZDZX01), Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence (LCNBI) and ZJLab, and the National Natural Science Foundation of China (Grant No. 12247101).

Corresponding Authors: Lianchun Yu,mE-mail:yulch@lzu.edu.cn;
E-mail: Lianchun Yu(俞连春)yulch@lzu.edu.cn;

Cite this article:

Haoran Yan(严浩然), Jiaqi Yan(颜家琦), Lianchun Yu(俞连春), and Yu-Feng Shao(邵玉峰) Cooperative activation of sodium channels for downgrading the energy efficiency in neuronal information processing 2024 Chin. Phys. B 33 058801

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Cooperative activation of sodium channels for downgrading the energy efficiency in neuronal information processing

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