Effect of applied electric fields on supralinear dendritic integration of interneuron
Ya-Qin Fan(樊亚琴)1, Xi-Le Wei(魏熙乐)1, Mei-Li Lu(卢梅丽)2, and Guo-Sheng Yi(伊国胜)1,†
1 Tianjin Key Laboratory of Process Measurement and Control, School of Electrical and Information Engineering, Tianjin University, Tianjin 300072, China; 2 School of Information Technology Engineering, Tianjin University of Technology and Education, Tianjin 300222, China
Abstract Evidences show that electric fields (EFs) induced by the magnetic stimulation could modulates brain activities by regulating the excitability of GABAergic interneuron. However, it is still unclear how and why the EF-induced polarization affects the interneuron response as the interneuron receives NMDA synaptic inputs. Considering the key role of NMDA receptor-mediated supralinear dendritic integration in neuronal computations, we suppose that the applied EFs could functionally modulate interneurons' response via regulating dendritic integration. At first, we build a simplified multi-dendritic circuit model with inhomogeneous extracellular potentials, which characterizes the relationship among EF-induced spatial polarizations, dendritic integration, and somatic output. By performing model-based singular perturbation analysis, it is found that the equilibrium point of fast subsystem can be used to asymptotically depict the subthreshold input-output (sI/O) relationship of dendritic integration. It predicted that EF-induced strong depolarizations on the distal dendrites reduce the dendritic saturation output by reducing driving force of synaptic input, and it shifts the steep change of sI/O curve left by reducing stimulation threshold of triggering NMDA spike. Also, the EF modulation prefers the global dendritic integration with asymmetric scatter distribution of NMDA synapses. Furthermore, we identify the respective contribution of EF-regulated dendritic integration and EF-induced somatic polarization to an action potential generation and find that they have an antagonistic effect on AP generation due to the varied NMDA spike threshold under EF stimulation.
Fund: Project supported by the National Natural Science Foundation of China (Grant No. 62171312) and the Tianjin Municipal Education Commission Scientific Research Project, China (Grant No. 2020KJ114).
Corresponding Authors:
Guo-Sheng Yi
E-mail: guoshengyi@tju.edu.cn
Cite this article:
Ya-Qin Fan(樊亚琴), Xi-Le Wei(魏熙乐), Mei-Li Lu(卢梅丽), and Guo-Sheng Yi(伊国胜) Effect of applied electric fields on supralinear dendritic integration of interneuron 2024 Chin. Phys. B 33 020202
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