Special Issue:
SPECIAL TOPIC — Modeling and simulations for the structures and functions of proteins and nucleic acids
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SPECIAL TOPIC—Modeling and simulations for the structures and functions of proteins and nucleic acids |
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Application of topological soliton in modeling protein folding: Recent progress and perspective |
Xu-Biao Peng(彭绪彪)1,†, Jiao-Jiao Liu(刘娇娇)1, Jin Dai(戴劲)1,2, Antti J Niemi1,2,‡, and Jian-Feng He(何建锋)1,§ |
1 School of Physics, Beijing Institute of Technology, Beijing 100081, China 2 Nordita, Stockholm University, Roslagstullsbacken 23, SE-106 91 Stockholm, Sweden |
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Abstract Proteins are important biological molecules whose structures are closely related to their specific functions. Understanding how the protein folds under physical principles, known as the protein folding problem, is one of the main tasks in modern biophysics. Coarse-grained methods play an increasingly important role in the simulation of protein folding, especially for large proteins. In recent years, we proposed a novel coarse-grained method derived from the topological soliton model, in terms of the backbone Cα chain. In this review, we will first systematically address the theoretical method of topological soliton. Then some successful applications will be displayed, including the thermodynamics simulation of protein folding, the property analysis of dynamic conformations, and the multi-scale simulation scheme. Finally, we will give a perspective on the development and application of topological soliton.
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Received: 30 June 2020
Revised: 08 August 2020
Accepted manuscript online: 13 August 2020
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PACS:
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87.15.Cc
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(Folding: thermodynamics, statistical mechanics, models, and pathways)
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87.14.E-
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(Proteins)
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87.15.A-
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(Theory, modeling, and computer simulation)
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87.15.hm
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(Folding dynamics)
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Corresponding Authors:
†E-mail: xubiaopeng@bit.edu.cn ‡E-mail: Antti.Niemi@physics.uu.se §Corresponding author. E-mail: hjf@bit.edu.cn
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Cite this article:
Xu-Biao Peng(彭绪彪)†, Jiao-Jiao Liu(刘娇娇), Jin Dai(戴劲), Antti J Niemi‡, and Jian-Feng He(何建锋)§ Application of topological soliton in modeling protein folding: Recent progress and perspective 2020 Chin. Phys. B 29 108705
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